Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects

Dongseong Shin,1,2 Young Sil Eom, 3,4 Suk Chon,5 Byung-Joon Kim, 3,4 Kyung-Sang Yu,6,* Dae Ho Lee 3,4,*1Department of Pharmacology, Gachon University College of Medicine, Incheon, Korea; 2Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea; 3Department of Internal Medicine,...

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Autores principales:	Shin D, Eom YS, Chon S, Kim BJ, Yu KS, Lee DH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	insulin sensitivity hyperinsulinemic-euglycemic clamp glucose disposal rate age Matsuda index Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/93ca5afbe4df40b292f3e736dc5c2192
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spelling	oai:doaj.org-article:93ca5afbe4df40b292f3e736dc5c21922021-12-02T04:05:55ZFactors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects1178-7007https://doaj.org/article/93ca5afbe4df40b292f3e736dc5c21922019-04-01T00:00:00Zhttps://www.dovepress.com/factors-influencing-insulin-sensitivity-during-hyperinsulinemic-euglyc-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Dongseong Shin,1,2 Young Sil Eom, 3,4 Suk Chon,5 Byung-Joon Kim, 3,4 Kyung-Sang Yu,6,* Dae Ho Lee 3,4,1Department of Pharmacology, Gachon University College of Medicine, Incheon, Korea; 2Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea; 3Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea; 4Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea; 5Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea; 6Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, KoreaThese authors contributed equally to this workBackground and objective: The effects of age and related factors on insulin sensitivity have not been definitively evaluated in East Asian populations. We proposed a reference range for the glucose disposal rate (M-value) on hyperinsulinemic-euglycemic study and its association with other parameters.Methods: Healthy, non-diabetic young (n=10) and elderly (n=13) male subjects with normal body mass index were eligible for this study. Subjects who passed the oral glucose tolerance test (OGTT) underwent hyperinsulinemic-euglycemic clamp with high-dose (80 mU/m2·min) insulin infusion.Results: M-values were normalized to body weight (MBW) and fat-free mass (MFFM). Neither M-value was significantly different between age groups (P=0.458 and P=0.900, respectively). An inverse correlation was observed between MFFM and baseline insulin (r=−0.418; P=0.047), baseline C-peptide (r=−0.426; P=0.043) and OGTT 2-hour glucose (r=−0.452; P=0.030). Regarding correlations with other insulin sensitivity indices, M-values were positively associated with the Matsuda index but not with homeostasis model assessment of insulin resistance.Conclusion: Our results suggest that age is not a critical determinant of insulin sensitivity, while fasting insulin and C-peptide levels, OGTT 2-hour glucose level, and Matsuda index are predictable markers of insulin sensitivity in healthy Koreans.Keywords: insulin sensitivity, hyperinsulinemic-euglycemic clamp, glucose disposal rate, age, Matsuda indexShin DEom YSChon SKim BJYu KSLee DHDove Medical Pressarticleinsulin sensitivityhyperinsulinemic-euglycemic clampglucose disposal rateageMatsuda indexSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 469-476 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	insulin sensitivity hyperinsulinemic-euglycemic clamp glucose disposal rate age Matsuda index Specialties of internal medicine RC581-951
spellingShingle	insulin sensitivity hyperinsulinemic-euglycemic clamp glucose disposal rate age Matsuda index Specialties of internal medicine RC581-951 Shin D Eom YS Chon S Kim BJ Yu KS Lee DH Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
description	Dongseong Shin,1,2 Young Sil Eom, 3,4 Suk Chon,5 Byung-Joon Kim, 3,4 Kyung-Sang Yu,6,* Dae Ho Lee 3,4,1Department of Pharmacology, Gachon University College of Medicine, Incheon, Korea; 2Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea; 3Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea; 4Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea; 5Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea; 6Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, KoreaThese authors contributed equally to this workBackground and objective: The effects of age and related factors on insulin sensitivity have not been definitively evaluated in East Asian populations. We proposed a reference range for the glucose disposal rate (M-value) on hyperinsulinemic-euglycemic study and its association with other parameters.Methods: Healthy, non-diabetic young (n=10) and elderly (n=13) male subjects with normal body mass index were eligible for this study. Subjects who passed the oral glucose tolerance test (OGTT) underwent hyperinsulinemic-euglycemic clamp with high-dose (80 mU/m2·min) insulin infusion.Results: M-values were normalized to body weight (MBW) and fat-free mass (MFFM). Neither M-value was significantly different between age groups (P=0.458 and P=0.900, respectively). An inverse correlation was observed between MFFM and baseline insulin (r=−0.418; P=0.047), baseline C-peptide (r=−0.426; P=0.043) and OGTT 2-hour glucose (r=−0.452; P=0.030). Regarding correlations with other insulin sensitivity indices, M-values were positively associated with the Matsuda index but not with homeostasis model assessment of insulin resistance.Conclusion: Our results suggest that age is not a critical determinant of insulin sensitivity, while fasting insulin and C-peptide levels, OGTT 2-hour glucose level, and Matsuda index are predictable markers of insulin sensitivity in healthy Koreans.Keywords: insulin sensitivity, hyperinsulinemic-euglycemic clamp, glucose disposal rate, age, Matsuda index
format	article
author	Shin D Eom YS Chon S Kim BJ Yu KS Lee DH
author_facet	Shin D Eom YS Chon S Kim BJ Yu KS Lee DH
author_sort	Shin D
title	Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
title_short	Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
title_full	Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
title_fullStr	Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
title_full_unstemmed	Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
title_sort	factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy korean male subjects
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/93ca5afbe4df40b292f3e736dc5c2192
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_version_	1718401445888262144

Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects

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