Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke

Abstract Individuals aged 80 years and older constitute the fastest growing segment of the population worldwide, leading to an expected increase in dementia cases. Education level and treatment of vascular risk factors has increased during the last decades. We examined whether this has influenced th...

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Autores principales:	Ingmar Skoog, Anne Börjesson-Hanson, Silke Kern, Lena Johansson, Hanna Falk, Robert Sigström, Svante Östling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93cdab9eca1943b09b119a3c28b28fbf
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spelling	oai:doaj.org-article:93cdab9eca1943b09b119a3c28b28fbf2021-12-02T16:06:44ZDecreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke10.1038/s41598-017-05022-82045-2322https://doaj.org/article/93cdab9eca1943b09b119a3c28b28fbf2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05022-8https://doaj.org/toc/2045-2322Abstract Individuals aged 80 years and older constitute the fastest growing segment of the population worldwide, leading to an expected increase in dementia cases. Education level and treatment of vascular risk factors has increased during the last decades. We examined whether this has influenced the prevalence of dementia according to DSM-III-R using population-based samples of 85-year-olds (N = 1065) examined with identical methods 1986–87 and 2008–10. The prevalence of dementia was 29.8% in 1986–87 and 21.7% in 2008–10 (OR 0.66; 95%-CI: 0.50–0.86). The decline was mainly observed for vascular dementia. The proportion with more than basic education (25.2% and 57.7%), and the prevalence of stroke (20% and 30%) increased, but the odds ratio for dementia with stroke decreased from 4.3 to 1.8 (interaction strokebirth cohort; p = 0.008). In a logistic regression, education (OR 0.70; 95%-CI 0.51–0.96), stroke (OR 3.78; 95%-CI 2.28–6.29), interaction strokebirth cohort (OR 0.50; 95%-CI 0.26–0.97), but not birth cohort (OR 0.98; 95%-CI 0.68–1.41), were related to prevalence of dementia. Thus, the decline in dementia prevalence was mainly explained by higher education and lower odds for dementia with stroke in later born birth cohorts. The findings may be related to an increased cognitive reserve and better treatment of stroke in later-born cohorts.Ingmar SkoogAnne Börjesson-HansonSilke KernLena JohanssonHanna FalkRobert SigströmSvante ÖstlingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ingmar Skoog Anne Börjesson-Hanson Silke Kern Lena Johansson Hanna Falk Robert Sigström Svante Östling Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke
description	Abstract Individuals aged 80 years and older constitute the fastest growing segment of the population worldwide, leading to an expected increase in dementia cases. Education level and treatment of vascular risk factors has increased during the last decades. We examined whether this has influenced the prevalence of dementia according to DSM-III-R using population-based samples of 85-year-olds (N = 1065) examined with identical methods 1986–87 and 2008–10. The prevalence of dementia was 29.8% in 1986–87 and 21.7% in 2008–10 (OR 0.66; 95%-CI: 0.50–0.86). The decline was mainly observed for vascular dementia. The proportion with more than basic education (25.2% and 57.7%), and the prevalence of stroke (20% and 30%) increased, but the odds ratio for dementia with stroke decreased from 4.3 to 1.8 (interaction strokebirth cohort; p = 0.008). In a logistic regression, education (OR 0.70; 95%-CI 0.51–0.96), stroke (OR 3.78; 95%-CI 2.28–6.29), interaction strokebirth cohort (OR 0.50; 95%-CI 0.26–0.97), but not birth cohort (OR 0.98; 95%-CI 0.68–1.41), were related to prevalence of dementia. Thus, the decline in dementia prevalence was mainly explained by higher education and lower odds for dementia with stroke in later born birth cohorts. The findings may be related to an increased cognitive reserve and better treatment of stroke in later-born cohorts.
format	article
author	Ingmar Skoog Anne Börjesson-Hanson Silke Kern Lena Johansson Hanna Falk Robert Sigström Svante Östling
author_facet	Ingmar Skoog Anne Börjesson-Hanson Silke Kern Lena Johansson Hanna Falk Robert Sigström Svante Östling
author_sort	Ingmar Skoog
title	Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke
title_short	Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke
title_full	Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke
title_fullStr	Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke
title_full_unstemmed	Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke
title_sort	decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/93cdab9eca1943b09b119a3c28b28fbf
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Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke

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