Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> to destroy factors that prevent serum-associa...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/93d02177691741d88b59540df58b1a29 |
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| Sumario: | Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> to destroy factors that prevent serum-associated, complement-directed killing. The protease activity also enhances bacterial susceptibility to antibiotics in sera. These findings implicate a new paradigm where host protease activity on bacteria acts combinatorially with the host complement system and antibiotics to defeat bacterial pathogens. |
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