Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing

Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> to destroy factors that prevent serum-associa...

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Autores principales:	Shaorong Chen, Dongmei Zhang, Alexandria-Jade Roberts, Hsueh-Chung Lu, Carolyn L. Cannon, Qing-Ming Qin, Paul de Figueiredo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	host immune system protease neutrophil elastase bacterial pathogens multidrug resistant bacteria host complement system antibiotics Medicine R
Acceso en línea:	https://doaj.org/article/93d02177691741d88b59540df58b1a29
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spelling	oai:doaj.org-article:93d02177691741d88b59540df58b1a292021-11-25T18:38:47ZHost Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing10.3390/pathogens101115062076-0817https://doaj.org/article/93d02177691741d88b59540df58b1a292021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1506https://doaj.org/toc/2076-0817Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> to destroy factors that prevent serum-associated, complement-directed killing. The protease activity also enhances bacterial susceptibility to antibiotics in sera. These findings implicate a new paradigm where host protease activity on bacteria acts combinatorially with the host complement system and antibiotics to defeat bacterial pathogens.Shaorong ChenDongmei ZhangAlexandria-Jade RobertsHsueh-Chung LuCarolyn L. CannonQing-Ming QinPaul de FigueiredoMDPI AGarticlehost immune systemprotease neutrophil elastasebacterial pathogensmultidrug resistant bacteriahost complement systemantibioticsMedicineRENPathogens, Vol 10, Iss 1506, p 1506 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	host immune system protease neutrophil elastase bacterial pathogens multidrug resistant bacteria host complement system antibiotics Medicine R
spellingShingle	host immune system protease neutrophil elastase bacterial pathogens multidrug resistant bacteria host complement system antibiotics Medicine R Shaorong Chen Dongmei Zhang Alexandria-Jade Roberts Hsueh-Chung Lu Carolyn L. Cannon Qing-Ming Qin Paul de Figueiredo Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
description	Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> to destroy factors that prevent serum-associated, complement-directed killing. The protease activity also enhances bacterial susceptibility to antibiotics in sera. These findings implicate a new paradigm where host protease activity on bacteria acts combinatorially with the host complement system and antibiotics to defeat bacterial pathogens.
format	article
author	Shaorong Chen Dongmei Zhang Alexandria-Jade Roberts Hsueh-Chung Lu Carolyn L. Cannon Qing-Ming Qin Paul de Figueiredo
author_facet	Shaorong Chen Dongmei Zhang Alexandria-Jade Roberts Hsueh-Chung Lu Carolyn L. Cannon Qing-Ming Qin Paul de Figueiredo
author_sort	Shaorong Chen
title	Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
title_short	Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
title_full	Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
title_fullStr	Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
title_full_unstemmed	Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
title_sort	host protease activity on bacterial pathogens promotes complement and antibiotic-directed killing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/93d02177691741d88b59540df58b1a29
work_keys_str_mv	AT shaorongchen hostproteaseactivityonbacterialpathogenspromotescomplementandantibioticdirectedkilling AT dongmeizhang hostproteaseactivityonbacterialpathogenspromotescomplementandantibioticdirectedkilling AT alexandriajaderoberts hostproteaseactivityonbacterialpathogenspromotescomplementandantibioticdirectedkilling AT hsuehchunglu hostproteaseactivityonbacterialpathogenspromotescomplementandantibioticdirectedkilling AT carolynlcannon hostproteaseactivityonbacterialpathogenspromotescomplementandantibioticdirectedkilling AT qingmingqin hostproteaseactivityonbacterialpathogenspromotescomplementandantibioticdirectedkilling AT pauldefigueiredo hostproteaseactivityonbacterialpathogenspromotescomplementandantibioticdirectedkilling
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Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing

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