$Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model$
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Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model

Abstract: Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16, 23”), showed pr...

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Autores principales:	Ana María Henao-Duque, Berardo de Jesús Rodríguez, Jaime Andrés Pereañez, Tatiana Lobo-Echeverri, Vitelbina Núñez Rangel
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia
Materias:	Leaf extract oral pathology Swietenia macrophylla toxicology Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/93d0c0df380a4fc8bf22050d7783da18
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spelling	oai:doaj.org-article:93d0c0df380a4fc8bf22050d7783da182021-12-02T07:01:15ZAcute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model0121-400410.17533/udea.vitae.v24n1a03https://doaj.org/article/93d0c0df380a4fc8bf22050d7783da18http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042017000100023&lng=en&tlng=enhttps://doaj.org/toc/0121-4004Abstract: Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16, 23”), showed promising results against some toxins of South American pit vipers. Objectives: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16, 23 from the leaf ethanolic extract, using Swiss Webster mice. Methods: Fraction Sm13-16, 23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/Kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and the binucleation were observed. Conclusions: Fraction Sm13-16, 23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low.Ana María Henao-DuqueBerardo de Jesús RodríguezJaime Andrés PereañezTatiana Lobo-EcheverriVitelbina Núñez RangelUniversidad de AntioquiaarticleLeaf extractoralpathologySwietenia macrophyllatoxicologyFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 24, Iss 1, Pp 23-29
institution	DOAJ
collection	DOAJ
language	EN
topic	Leaf extract oral pathology Swietenia macrophylla toxicology Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Leaf extract oral pathology Swietenia macrophylla toxicology Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Ana María Henao-Duque Berardo de Jesús Rodríguez Jaime Andrés Pereañez Tatiana Lobo-Echeverri Vitelbina Núñez Rangel Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model
description	Abstract: Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16, 23”), showed promising results against some toxins of South American pit vipers. Objectives: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16, 23 from the leaf ethanolic extract, using Swiss Webster mice. Methods: Fraction Sm13-16, 23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/Kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and the binucleation were observed. Conclusions: Fraction Sm13-16, 23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low.
format	article
author	Ana María Henao-Duque Berardo de Jesús Rodríguez Jaime Andrés Pereañez Tatiana Lobo-Echeverri Vitelbina Núñez Rangel
author_facet	Ana María Henao-Duque Berardo de Jesús Rodríguez Jaime Andrés Pereañez Tatiana Lobo-Echeverri Vitelbina Núñez Rangel
author_sort	Ana María Henao-Duque
title	Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model
title_short	Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model
title_full	Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model
title_fullStr	Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model
title_full_unstemmed	Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model
title_sort	acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of swietenia macrophylla king in a murine model
publisher	Universidad de Antioquia
url	https://doaj.org/article/93d0c0df380a4fc8bf22050d7783da18
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Acute oral toxicity from a fraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model

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