Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model

Abstract The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) modulate ER signaling and downstream cellular respons...

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Autores principales: Molly M. Morgan, Megan K. Livingston, Jay W. Warrick, Eli M. Stanek, Elaine T. Alarid, David J. Beebe, Brian P. Johnson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/93d31729cd3141899c8dc7350744dfce
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