DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity

DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity

In yeast, TFIP11 and DHX15 promote the disassembly of spliceosome complex after splicing is completed. Here the authors show that human TFIP11 functions independently of DHX15 and is required for U6 snRNA 2’-O-methylation and U4/U6.U5 tri-snRNP assembly.

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Autores principales: Amandine Duchemin, Tina O’Grady, Sarah Hanache, Agnès Mereau, Marc Thiry, Ludivine Wacheul, Catherine Michaux, Eric Perpète, Eric Hervouet, Paul Peixoto, Felix G. M. Ernst, Yann Audic, Franck Dequiedt, Denis L. J. Lafontaine, Denis Mottet
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/93d4369760d94698a2204e30cd575392
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spelling oai:doaj.org-article:93d4369760d94698a2204e30cd5753922021-11-21T12:35:13ZDHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity10.1038/s41467-021-26932-22041-1723https://doaj.org/article/93d4369760d94698a2204e30cd5753922021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26932-2https://doaj.org/toc/2041-1723In yeast, TFIP11 and DHX15 promote the disassembly of spliceosome complex after splicing is completed. Here the authors show that human TFIP11 functions independently of DHX15 and is required for U6 snRNA 2’-O-methylation and U4/U6.U5 tri-snRNP assembly.Amandine DucheminTina O’GradySarah HanacheAgnès MereauMarc ThiryLudivine WacheulCatherine MichauxEric PerpèteEric HervouetPaul PeixotoFelix G. M. ErnstYann AudicFranck DequiedtDenis L. J. LafontaineDenis MottetNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Amandine Duchemin
Tina O’Grady
Sarah Hanache
Agnès Mereau
Marc Thiry
Ludivine Wacheul
Catherine Michaux
Eric Perpète
Eric Hervouet
Paul Peixoto
Felix G. M. Ernst
Yann Audic
Franck Dequiedt
Denis L. J. Lafontaine
Denis Mottet
DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity
description In yeast, TFIP11 and DHX15 promote the disassembly of spliceosome complex after splicing is completed. Here the authors show that human TFIP11 functions independently of DHX15 and is required for U6 snRNA 2’-O-methylation and U4/U6.U5 tri-snRNP assembly.
format article
author Amandine Duchemin
Tina O’Grady
Sarah Hanache
Agnès Mereau
Marc Thiry
Ludivine Wacheul
Catherine Michaux
Eric Perpète
Eric Hervouet
Paul Peixoto
Felix G. M. Ernst
Yann Audic
Franck Dequiedt
Denis L. J. Lafontaine
Denis Mottet
author_facet Amandine Duchemin
Tina O’Grady
Sarah Hanache
Agnès Mereau
Marc Thiry
Ludivine Wacheul
Catherine Michaux
Eric Perpète
Eric Hervouet
Paul Peixoto
Felix G. M. Ernst
Yann Audic
Franck Dequiedt
Denis L. J. Lafontaine
Denis Mottet
author_sort Amandine Duchemin
title DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity
title_short DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity
title_full DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity
title_fullStr DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity
title_full_unstemmed DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity
title_sort dhx15-independent roles for tfip11 in u6 snrna modification, u4/u6.u5 tri-snrnp assembly and pre-mrna splicing fidelity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/93d4369760d94698a2204e30cd575392
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