Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Abstract Iron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging (MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH), due to the rise in temperature they provoke under an Alternating Magnetic Field (AMF). Micrometric IOP have a high s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Laurence Dallet, Dimitri Stanicki, Pierre Voisin, Sylvain Miraux, Emeline J. Ribot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93d6d5446189439eb79f6b4e4a5560a2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:93d6d5446189439eb79f6b4e4a5560a2
record_format	dspace
spelling	oai:doaj.org-article:93d6d5446189439eb79f6b4e4a5560a22021-12-02T13:30:10ZMicron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment10.1038/s41598-021-82095-62045-2322https://doaj.org/article/93d6d5446189439eb79f6b4e4a5560a22021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82095-6https://doaj.org/toc/2045-2322Abstract Iron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging (MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH), due to the rise in temperature they provoke under an Alternating Magnetic Field (AMF). Micrometric IOP have a high sensitivity of detection. Nevertheless, little is known about their internalization processes or their potential heat power. Two micrometric commercial IOP (from Bangs Laboratories and Chemicell) were characterized by Transmission Electron Microscopy (TEM) and their endocytic pathways into glioma cells were analyzed. Their Specific Absorption Rate (SAR) and cytotoxicity were evaluated using a commercial AMF inductor. T2-weighted imaging was used to monitor tumor growth in vivo after MFH treatment in mice. The two micron-sized IOP had similar structures and r2 relaxivities (100 mM−1 s−1) but involved different endocytic pathways. Only ScreenMAG particles generated a significant rise in temperature following AMF (SAR = 113 W g−1 Fe). After 1 h of AMF exposure, 60% of ScreenMAG-labeled cells died. Translated to a glioma model, 89% of mice responded to the treatment with smaller tumor volume 42 days post-implantation. Micrometric particles were investigated from their characterization to their intracellular internalization pathways and applied in one in vivo cancer treatment, i.e. MFH.Laurence DalletDimitri StanickiPierre VoisinSylvain MirauxEmeline J. RibotNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laurence Dallet Dimitri Stanicki Pierre Voisin Sylvain Miraux Emeline J. Ribot Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment
description	Abstract Iron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging (MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH), due to the rise in temperature they provoke under an Alternating Magnetic Field (AMF). Micrometric IOP have a high sensitivity of detection. Nevertheless, little is known about their internalization processes or their potential heat power. Two micrometric commercial IOP (from Bangs Laboratories and Chemicell) were characterized by Transmission Electron Microscopy (TEM) and their endocytic pathways into glioma cells were analyzed. Their Specific Absorption Rate (SAR) and cytotoxicity were evaluated using a commercial AMF inductor. T2-weighted imaging was used to monitor tumor growth in vivo after MFH treatment in mice. The two micron-sized IOP had similar structures and r2 relaxivities (100 mM−1 s−1) but involved different endocytic pathways. Only ScreenMAG particles generated a significant rise in temperature following AMF (SAR = 113 W g−1 Fe). After 1 h of AMF exposure, 60% of ScreenMAG-labeled cells died. Translated to a glioma model, 89% of mice responded to the treatment with smaller tumor volume 42 days post-implantation. Micrometric particles were investigated from their characterization to their intracellular internalization pathways and applied in one in vivo cancer treatment, i.e. MFH.
format	article
author	Laurence Dallet Dimitri Stanicki Pierre Voisin Sylvain Miraux Emeline J. Ribot
author_facet	Laurence Dallet Dimitri Stanicki Pierre Voisin Sylvain Miraux Emeline J. Ribot
author_sort	Laurence Dallet
title	Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment
title_short	Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment
title_full	Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment
title_fullStr	Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment
title_full_unstemmed	Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment
title_sort	micron-sized iron oxide particles for both mri cell tracking and magnetic fluid hyperthermia treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93d6d5446189439eb79f6b4e4a5560a2
work_keys_str_mv	AT laurencedallet micronsizedironoxideparticlesforbothmricelltrackingandmagneticfluidhyperthermiatreatment AT dimitristanicki micronsizedironoxideparticlesforbothmricelltrackingandmagneticfluidhyperthermiatreatment AT pierrevoisin micronsizedironoxideparticlesforbothmricelltrackingandmagneticfluidhyperthermiatreatment AT sylvainmiraux micronsizedironoxideparticlesforbothmricelltrackingandmagneticfluidhyperthermiatreatment AT emelinejribot micronsizedironoxideparticlesforbothmricelltrackingandmagneticfluidhyperthermiatreatment
_version_	1718392989609361408

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Ejemplares similares