Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality

Abstract We determined sex differences in the prevalence of obstructive sleep apnea (OSA) among patients hospitalized with pulmonary embolism (PE) in Spain (2016–2018). We also compared outcomes according to the presence of OSA, and identified variables associated with in-hospital-mortality (IHM) af...

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Autores principales:	Javier de-Miguel-Diez, Marta Lopez-Herranz, Valentín Hernandez-Barrera, David Jimenez, Manuel Monreal, Rodrigo Jiménez-García, Ana López-de-Andrés
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93d935adeb444cec8f9f94a11de2f935
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spelling	oai:doaj.org-article:93d935adeb444cec8f9f94a11de2f9352021-12-02T18:50:52ZSex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality10.1038/s41598-021-97923-y2045-2322https://doaj.org/article/93d935adeb444cec8f9f94a11de2f9352021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97923-yhttps://doaj.org/toc/2045-2322Abstract We determined sex differences in the prevalence of obstructive sleep apnea (OSA) among patients hospitalized with pulmonary embolism (PE) in Spain (2016–2018). We also compared outcomes according to the presence of OSA, and identified variables associated with in-hospital-mortality (IHM) after PE using the Spanish National Hospital Discharge Database. We identified 46,794 hospital admissions for PE; of these, 5.47% had OSA. OSA was more prevalent among men than women (7.57% vs. 3.65%, p < 0.001), as in the general population. Propensity score matching did not reveal differences in concomitant conditions or procedures between patients with and without OSA, except for the use of non-invasive ventilation, which was more frequent in patients with OSA. IHM was similar in patients with and without OSA (3.58% vs. 4.31% for men and 4.39% vs. 4.93% for women; p > 0.05). Older age, cancer, atrial fibrillation, non-septic shock, and need for mechanical ventilation increased IHM in men and women with OSA hospitalized with PE. The logistic regression model showed no sex differences in IHM among patients with OSA.Javier de-Miguel-DiezMarta Lopez-HerranzValentín Hernandez-BarreraDavid JimenezManuel MonrealRodrigo Jiménez-GarcíaAna López-de-AndrésNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Javier de-Miguel-Diez Marta Lopez-Herranz Valentín Hernandez-Barrera David Jimenez Manuel Monreal Rodrigo Jiménez-García Ana López-de-Andrés Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality
description	Abstract We determined sex differences in the prevalence of obstructive sleep apnea (OSA) among patients hospitalized with pulmonary embolism (PE) in Spain (2016–2018). We also compared outcomes according to the presence of OSA, and identified variables associated with in-hospital-mortality (IHM) after PE using the Spanish National Hospital Discharge Database. We identified 46,794 hospital admissions for PE; of these, 5.47% had OSA. OSA was more prevalent among men than women (7.57% vs. 3.65%, p < 0.001), as in the general population. Propensity score matching did not reveal differences in concomitant conditions or procedures between patients with and without OSA, except for the use of non-invasive ventilation, which was more frequent in patients with OSA. IHM was similar in patients with and without OSA (3.58% vs. 4.31% for men and 4.39% vs. 4.93% for women; p > 0.05). Older age, cancer, atrial fibrillation, non-septic shock, and need for mechanical ventilation increased IHM in men and women with OSA hospitalized with PE. The logistic regression model showed no sex differences in IHM among patients with OSA.
format	article
author	Javier de-Miguel-Diez Marta Lopez-Herranz Valentín Hernandez-Barrera David Jimenez Manuel Monreal Rodrigo Jiménez-García Ana López-de-Andrés
author_facet	Javier de-Miguel-Diez Marta Lopez-Herranz Valentín Hernandez-Barrera David Jimenez Manuel Monreal Rodrigo Jiménez-García Ana López-de-Andrés
author_sort	Javier de-Miguel-Diez
title	Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality
title_short	Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality
title_full	Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality
title_fullStr	Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality
title_full_unstemmed	Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality
title_sort	sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93d935adeb444cec8f9f94a11de2f935
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Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality

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