Nanobacteria are mineralo fetuin complexes.

"Nanobacteria" are nanometer-scale spherical and ovoid particles which have spurred one of the biggest controversies in modern microbiology. Their biological nature has been severely challenged by both geologists and microbiologists, with opinions ranging from considering them crystal stru...

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Autores principales:	Didier Raoult, Michel Drancourt, Saïd Azza, Claude Nappez, Régis Guieu, Jean-Marc Rolain, Patrick Fourquet, Bernard Campagna, Bernard La Scola, Jean-Louis Mege, Pascal Mansuelle, Eric Lechevalier, Yvon Berland, Jean-Pierre Gorvel, Patricia Renesto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/93d9c16bb68149b39fbf5e834989e54f
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id	oai:doaj.org-article:93d9c16bb68149b39fbf5e834989e54f
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spelling	oai:doaj.org-article:93d9c16bb68149b39fbf5e834989e54f2021-11-25T05:46:43ZNanobacteria are mineralo fetuin complexes.1553-73661553-737410.1371/journal.ppat.0040041https://doaj.org/article/93d9c16bb68149b39fbf5e834989e54f2008-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18282102/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374"Nanobacteria" are nanometer-scale spherical and ovoid particles which have spurred one of the biggest controversies in modern microbiology. Their biological nature has been severely challenged by both geologists and microbiologists, with opinions ranging from considering them crystal structures to new life forms. Although the nature of these autonomously replicating particles is still under debate, their role in several calcification-related diseases has been reported. In order to gain better insights on this calciferous agent, we performed a large-scale project, including the analysis of "nanobacteria" susceptibility to physical and chemical compounds as well as the comprehensive nucleotide, biochemical, proteomic, and antigenic analysis of these particles. Our results definitively ruled out the existence of "nanobacteria" as living organisms and pointed out the paradoxical role of fetuin (an anti-mineralization protein) in the formation of these self-propagating mineral complexes which we propose to call "nanons." The presence of fetuin within renal calculi was also evidenced, suggesting its role as a hydroxyapatite nucleating factor.Didier RaoultMichel DrancourtSaïd AzzaClaude NappezRégis GuieuJean-Marc RolainPatrick FourquetBernard CampagnaBernard La ScolaJean-Louis MegePascal MansuelleEric LechevalierYvon BerlandJean-Pierre GorvelPatricia RenestoPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 2, p e41 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Didier Raoult Michel Drancourt Saïd Azza Claude Nappez Régis Guieu Jean-Marc Rolain Patrick Fourquet Bernard Campagna Bernard La Scola Jean-Louis Mege Pascal Mansuelle Eric Lechevalier Yvon Berland Jean-Pierre Gorvel Patricia Renesto Nanobacteria are mineralo fetuin complexes.
description	"Nanobacteria" are nanometer-scale spherical and ovoid particles which have spurred one of the biggest controversies in modern microbiology. Their biological nature has been severely challenged by both geologists and microbiologists, with opinions ranging from considering them crystal structures to new life forms. Although the nature of these autonomously replicating particles is still under debate, their role in several calcification-related diseases has been reported. In order to gain better insights on this calciferous agent, we performed a large-scale project, including the analysis of "nanobacteria" susceptibility to physical and chemical compounds as well as the comprehensive nucleotide, biochemical, proteomic, and antigenic analysis of these particles. Our results definitively ruled out the existence of "nanobacteria" as living organisms and pointed out the paradoxical role of fetuin (an anti-mineralization protein) in the formation of these self-propagating mineral complexes which we propose to call "nanons." The presence of fetuin within renal calculi was also evidenced, suggesting its role as a hydroxyapatite nucleating factor.
format	article
author	Didier Raoult Michel Drancourt Saïd Azza Claude Nappez Régis Guieu Jean-Marc Rolain Patrick Fourquet Bernard Campagna Bernard La Scola Jean-Louis Mege Pascal Mansuelle Eric Lechevalier Yvon Berland Jean-Pierre Gorvel Patricia Renesto
author_facet	Didier Raoult Michel Drancourt Saïd Azza Claude Nappez Régis Guieu Jean-Marc Rolain Patrick Fourquet Bernard Campagna Bernard La Scola Jean-Louis Mege Pascal Mansuelle Eric Lechevalier Yvon Berland Jean-Pierre Gorvel Patricia Renesto
author_sort	Didier Raoult
title	Nanobacteria are mineralo fetuin complexes.
title_short	Nanobacteria are mineralo fetuin complexes.
title_full	Nanobacteria are mineralo fetuin complexes.
title_fullStr	Nanobacteria are mineralo fetuin complexes.
title_full_unstemmed	Nanobacteria are mineralo fetuin complexes.
title_sort	nanobacteria are mineralo fetuin complexes.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/93d9c16bb68149b39fbf5e834989e54f
work_keys_str_mv	AT didierraoult nanobacteriaaremineralofetuincomplexes AT micheldrancourt nanobacteriaaremineralofetuincomplexes AT saidazza nanobacteriaaremineralofetuincomplexes AT claudenappez nanobacteriaaremineralofetuincomplexes AT regisguieu nanobacteriaaremineralofetuincomplexes AT jeanmarcrolain nanobacteriaaremineralofetuincomplexes AT patrickfourquet nanobacteriaaremineralofetuincomplexes AT bernardcampagna nanobacteriaaremineralofetuincomplexes AT bernardlascola nanobacteriaaremineralofetuincomplexes AT jeanlouismege nanobacteriaaremineralofetuincomplexes AT pascalmansuelle nanobacteriaaremineralofetuincomplexes AT ericlechevalier nanobacteriaaremineralofetuincomplexes AT yvonberland nanobacteriaaremineralofetuincomplexes AT jeanpierregorvel nanobacteriaaremineralofetuincomplexes AT patriciarenesto nanobacteriaaremineralofetuincomplexes
_version_	1718414470803357696

Nanobacteria are mineralo fetuin complexes.

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