Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein

Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. Objectives: To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammation in rats. Materials and methods: Wistar Male rats (180–220 g) were...

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Autores principales: Abdullah S. Shatoor, Suliman Al Humayed, Mahmoud A. Alkhateeb, Khalid A. Shatoor, Hussain Aldera, Mohammed Alassiri, Ali A. Shati
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Publicado: Taylor & Francis Group 2019
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spelling oai:doaj.org-article:93dadb5bf7ea44f1a388f513791159f22021-11-17T14:21:55ZCrataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein1388-02091744-511610.1080/13880209.2018.1564930https://doaj.org/article/93dadb5bf7ea44f1a388f513791159f22019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2018.1564930https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. Objectives: To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammation in rats. Materials and methods: Wistar Male rats (180–220 g) were divided (n = 10/group) as control fed a standard diet (STD), STD + C. aronia (200 mg/kg, orally), HFD, HFD + C. aronia and HFD post-treated with C. aronia. Simvastatin (20 mg/kg) was co- or post-administered as a positive control drug. HFD was given for 8 weeks, and all other treatments were administered for 4 weeks. Results: Most significantly, co-administration of C. aronia to HFD-fed rats reduced the thickness of aorta tunica media (90 ± 5 vs. 160 ± 11.3 µm) and adventitia (54.3 ± 3.8 vs. 93.6 ± 9.4 µm). It also lowered protein levels of TNF-α (0.51 ± 0.15 and 0.15 ± 0.16 vs. 0.1 ± 0.09%) and IL-6 (0.52 ± 0.19 vs. 1.0 ± 0.2%) in their aorta or serum (5.9 ± 0.91 vs. 12.98 ± 1.3 ng/mL and 78.1 ± 6.7 vs. 439 ± 78 pg/mL, respectively). It also lowered all serum lipids and increased aorta levels of GSH levels (70.4 ± 4.0 vs. 40.7 µM) and activity of SOD (5.7 ± 0.7 vs. 2.9 ± 0.6 U/mg) and decreased serum levels of ox-LDL-c (566.7 ± 46 vs. 1817 ± 147 ng/mL). Such effects were more profound than all other treatments. Conclusions: C. aronia inhibits the HFD-induced vascular inflammation and its use in clinical trials is recommended.Abdullah S. ShatoorSuliman Al HumayedMahmoud A. AlkhateebKhalid A. ShatoorHussain AlderaMohammed AlassiriAli A. ShatiTaylor & Francis Grouparticlehyperlipidemiaatherosclerosisaortaoxidative stressTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 37-47 (2019)
institution DOAJ
collection DOAJ
language EN
topic hyperlipidemia
atherosclerosis
aorta
oxidative stress
Therapeutics. Pharmacology
RM1-950
spellingShingle hyperlipidemia
atherosclerosis
aorta
oxidative stress
Therapeutics. Pharmacology
RM1-950
Abdullah S. Shatoor
Suliman Al Humayed
Mahmoud A. Alkhateeb
Khalid A. Shatoor
Hussain Aldera
Mohammed Alassiri
Ali A. Shati
Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
description Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. Objectives: To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammation in rats. Materials and methods: Wistar Male rats (180–220 g) were divided (n = 10/group) as control fed a standard diet (STD), STD + C. aronia (200 mg/kg, orally), HFD, HFD + C. aronia and HFD post-treated with C. aronia. Simvastatin (20 mg/kg) was co- or post-administered as a positive control drug. HFD was given for 8 weeks, and all other treatments were administered for 4 weeks. Results: Most significantly, co-administration of C. aronia to HFD-fed rats reduced the thickness of aorta tunica media (90 ± 5 vs. 160 ± 11.3 µm) and adventitia (54.3 ± 3.8 vs. 93.6 ± 9.4 µm). It also lowered protein levels of TNF-α (0.51 ± 0.15 and 0.15 ± 0.16 vs. 0.1 ± 0.09%) and IL-6 (0.52 ± 0.19 vs. 1.0 ± 0.2%) in their aorta or serum (5.9 ± 0.91 vs. 12.98 ± 1.3 ng/mL and 78.1 ± 6.7 vs. 439 ± 78 pg/mL, respectively). It also lowered all serum lipids and increased aorta levels of GSH levels (70.4 ± 4.0 vs. 40.7 µM) and activity of SOD (5.7 ± 0.7 vs. 2.9 ± 0.6 U/mg) and decreased serum levels of ox-LDL-c (566.7 ± 46 vs. 1817 ± 147 ng/mL). Such effects were more profound than all other treatments. Conclusions: C. aronia inhibits the HFD-induced vascular inflammation and its use in clinical trials is recommended.
format article
author Abdullah S. Shatoor
Suliman Al Humayed
Mahmoud A. Alkhateeb
Khalid A. Shatoor
Hussain Aldera
Mohammed Alassiri
Ali A. Shati
author_facet Abdullah S. Shatoor
Suliman Al Humayed
Mahmoud A. Alkhateeb
Khalid A. Shatoor
Hussain Aldera
Mohammed Alassiri
Ali A. Shati
author_sort Abdullah S. Shatoor
title Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
title_short Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
title_full Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
title_fullStr Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
title_full_unstemmed Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
title_sort crataegus aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
publisher Taylor & Francis Group
publishDate 2019
url https://doaj.org/article/93dadb5bf7ea44f1a388f513791159f2
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