Mammalian γ2 AMPK regulates intrinsic heart rate

AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive b...

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Autores principales:	Arash Yavari, Mohamed Bellahcene, Annalisa Bucchi, Syevda Sirenko, Katalin Pinter, Neil Herring, Julia J. Jung, Kirill V. Tarasov, Emily J. Sharpe, Markus Wolfien, Gabor Czibik, Violetta Steeples, Sahar Ghaffari, Chinh Nguyen, Alexander Stockenhuber, Joshua R. St. Clair, Christian Rimmbach, Yosuke Okamoto, Dongmei Yang, Mingyi Wang, Bruce D. Ziman, Jack M. Moen, Daniel R. Riordon, Christopher Ramirez, Manuel Paina, Joonho Lee, Jing Zhang, Ismayil Ahmet, Michael G. Matt, Yelena S. Tarasova, Dilair Baban, Natasha Sahgal, Helen Lockstone, Rathi Puliyadi, Joseph de Bono, Owen M. Siggs, John Gomes, Hannah Muskett, Mahon L. Maguire, Youlia Beglov, Matthew Kelly, Pedro P. N. dos Santos, Nicola J. Bright, Angela Woods, Katja Gehmlich, Henrik Isackson, Gillian Douglas, David J. P. Ferguson, Jürgen E. Schneider, Andrew Tinker, Olaf Wolkenhauer, Keith M. Channon, Richard J. Cornall, Eduardo B. Sternick, David J. Paterson, Charles S. Redwood, David Carling, Catherine Proenza, Robert David, Mirko Baruscotti, Dario DiFrancesco, Edward G. Lakatta, Hugh Watkins, Houman Ashrafian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93dc1bb6f94248b0bbd5f23512479816
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spelling	oai:doaj.org-article:93dc1bb6f94248b0bbd5f235124798162021-12-02T17:06:30ZMammalian γ2 AMPK regulates intrinsic heart rate10.1038/s41467-017-01342-52041-1723https://doaj.org/article/93dc1bb6f94248b0bbd5f235124798162017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01342-5https://doaj.org/toc/2041-1723AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive bradycardia of endurance training in mice.Arash YavariMohamed BellahceneAnnalisa BucchiSyevda SirenkoKatalin PinterNeil HerringJulia J. JungKirill V. TarasovEmily J. SharpeMarkus WolfienGabor CzibikVioletta SteeplesSahar GhaffariChinh NguyenAlexander StockenhuberJoshua R. St. ClairChristian RimmbachYosuke OkamotoDongmei YangMingyi WangBruce D. ZimanJack M. MoenDaniel R. RiordonChristopher RamirezManuel PainaJoonho LeeJing ZhangIsmayil AhmetMichael G. MattYelena S. TarasovaDilair BabanNatasha SahgalHelen LockstoneRathi PuliyadiJoseph de BonoOwen M. SiggsJohn GomesHannah MuskettMahon L. MaguireYoulia BeglovMatthew KellyPedro P. N. dos SantosNicola J. BrightAngela WoodsKatja GehmlichHenrik IsacksonGillian DouglasDavid J. P. FergusonJürgen E. SchneiderAndrew TinkerOlaf WolkenhauerKeith M. ChannonRichard J. CornallEduardo B. SternickDavid J. PatersonCharles S. RedwoodDavid CarlingCatherine ProenzaRobert DavidMirko BaruscottiDario DiFrancescoEdward G. LakattaHugh WatkinsHouman AshrafianNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arash Yavari Mohamed Bellahcene Annalisa Bucchi Syevda Sirenko Katalin Pinter Neil Herring Julia J. Jung Kirill V. Tarasov Emily J. Sharpe Markus Wolfien Gabor Czibik Violetta Steeples Sahar Ghaffari Chinh Nguyen Alexander Stockenhuber Joshua R. St. Clair Christian Rimmbach Yosuke Okamoto Dongmei Yang Mingyi Wang Bruce D. Ziman Jack M. Moen Daniel R. Riordon Christopher Ramirez Manuel Paina Joonho Lee Jing Zhang Ismayil Ahmet Michael G. Matt Yelena S. Tarasova Dilair Baban Natasha Sahgal Helen Lockstone Rathi Puliyadi Joseph de Bono Owen M. Siggs John Gomes Hannah Muskett Mahon L. Maguire Youlia Beglov Matthew Kelly Pedro P. N. dos Santos Nicola J. Bright Angela Woods Katja Gehmlich Henrik Isackson Gillian Douglas David J. P. Ferguson Jürgen E. Schneider Andrew Tinker Olaf Wolkenhauer Keith M. Channon Richard J. Cornall Eduardo B. Sternick David J. Paterson Charles S. Redwood David Carling Catherine Proenza Robert David Mirko Baruscotti Dario DiFrancesco Edward G. Lakatta Hugh Watkins Houman Ashrafian Mammalian γ2 AMPK regulates intrinsic heart rate
description	AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive bradycardia of endurance training in mice.
format	article
author	Arash Yavari Mohamed Bellahcene Annalisa Bucchi Syevda Sirenko Katalin Pinter Neil Herring Julia J. Jung Kirill V. Tarasov Emily J. Sharpe Markus Wolfien Gabor Czibik Violetta Steeples Sahar Ghaffari Chinh Nguyen Alexander Stockenhuber Joshua R. St. Clair Christian Rimmbach Yosuke Okamoto Dongmei Yang Mingyi Wang Bruce D. Ziman Jack M. Moen Daniel R. Riordon Christopher Ramirez Manuel Paina Joonho Lee Jing Zhang Ismayil Ahmet Michael G. Matt Yelena S. Tarasova Dilair Baban Natasha Sahgal Helen Lockstone Rathi Puliyadi Joseph de Bono Owen M. Siggs John Gomes Hannah Muskett Mahon L. Maguire Youlia Beglov Matthew Kelly Pedro P. N. dos Santos Nicola J. Bright Angela Woods Katja Gehmlich Henrik Isackson Gillian Douglas David J. P. Ferguson Jürgen E. Schneider Andrew Tinker Olaf Wolkenhauer Keith M. Channon Richard J. Cornall Eduardo B. Sternick David J. Paterson Charles S. Redwood David Carling Catherine Proenza Robert David Mirko Baruscotti Dario DiFrancesco Edward G. Lakatta Hugh Watkins Houman Ashrafian
author_facet	Arash Yavari Mohamed Bellahcene Annalisa Bucchi Syevda Sirenko Katalin Pinter Neil Herring Julia J. Jung Kirill V. Tarasov Emily J. Sharpe Markus Wolfien Gabor Czibik Violetta Steeples Sahar Ghaffari Chinh Nguyen Alexander Stockenhuber Joshua R. St. Clair Christian Rimmbach Yosuke Okamoto Dongmei Yang Mingyi Wang Bruce D. Ziman Jack M. Moen Daniel R. Riordon Christopher Ramirez Manuel Paina Joonho Lee Jing Zhang Ismayil Ahmet Michael G. Matt Yelena S. Tarasova Dilair Baban Natasha Sahgal Helen Lockstone Rathi Puliyadi Joseph de Bono Owen M. Siggs John Gomes Hannah Muskett Mahon L. Maguire Youlia Beglov Matthew Kelly Pedro P. N. dos Santos Nicola J. Bright Angela Woods Katja Gehmlich Henrik Isackson Gillian Douglas David J. P. Ferguson Jürgen E. Schneider Andrew Tinker Olaf Wolkenhauer Keith M. Channon Richard J. Cornall Eduardo B. Sternick David J. Paterson Charles S. Redwood David Carling Catherine Proenza Robert David Mirko Baruscotti Dario DiFrancesco Edward G. Lakatta Hugh Watkins Houman Ashrafian
author_sort	Arash Yavari
title	Mammalian γ2 AMPK regulates intrinsic heart rate
title_short	Mammalian γ2 AMPK regulates intrinsic heart rate
title_full	Mammalian γ2 AMPK regulates intrinsic heart rate
title_fullStr	Mammalian γ2 AMPK regulates intrinsic heart rate
title_full_unstemmed	Mammalian γ2 AMPK regulates intrinsic heart rate
title_sort	mammalian γ2 ampk regulates intrinsic heart rate
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/93dc1bb6f94248b0bbd5f23512479816
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Mammalian γ2 AMPK regulates intrinsic heart rate

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