CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis

Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression of inflammatory Th17 cells and M1 macrophages...

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Autores principales:	Guangyong Sun, Xinyan Zhao, Mingyang Li, Chunpan Zhang, Hua Jin, Changying Li, Liwei Liu, Yaning Wang, Wen Shi, Dan Tian, Hufeng Xu, Yue Tian, Yongle Wu, Kai Liu, Zhongtao Zhang, Dong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93e743386e634a6eb1817b7b407cee22
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spelling	oai:doaj.org-article:93e743386e634a6eb1817b7b407cee222021-12-02T13:24:33ZCD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis10.1038/s41467-021-20941-x2041-1723https://doaj.org/article/93e743386e634a6eb1817b7b407cee222021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20941-xhttps://doaj.org/toc/2041-1723Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression of inflammatory Th17 cells and M1 macrophages in mouse models.Guangyong SunXinyan ZhaoMingyang LiChunpan ZhangHua JinChangying LiLiwei LiuYaning WangWen ShiDan TianHufeng XuYue TianYongle WuKai LiuZhongtao ZhangDong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guangyong Sun Xinyan Zhao Mingyang Li Chunpan Zhang Hua Jin Changying Li Liwei Liu Yaning Wang Wen Shi Dan Tian Hufeng Xu Yue Tian Yongle Wu Kai Liu Zhongtao Zhang Dong Zhang CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis
description	Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression of inflammatory Th17 cells and M1 macrophages in mouse models.
format	article
author	Guangyong Sun Xinyan Zhao Mingyang Li Chunpan Zhang Hua Jin Changying Li Liwei Liu Yaning Wang Wen Shi Dan Tian Hufeng Xu Yue Tian Yongle Wu Kai Liu Zhongtao Zhang Dong Zhang
author_facet	Guangyong Sun Xinyan Zhao Mingyang Li Chunpan Zhang Hua Jin Changying Li Liwei Liu Yaning Wang Wen Shi Dan Tian Hufeng Xu Yue Tian Yongle Wu Kai Liu Zhongtao Zhang Dong Zhang
author_sort	Guangyong Sun
title	CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis
title_short	CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis
title_full	CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis
title_fullStr	CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis
title_full_unstemmed	CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis
title_sort	cd4 derived double negative t cells prevent the development and progression of nonalcoholic steatohepatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93e743386e634a6eb1817b7b407cee22
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CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis

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