An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale

Abstract Bone is an intriguingly complex material. It combines high strength, toughness and lightweight via an elaborate hierarchical structure. This structure results from a biologically driven self-assembly and self-organisation, and leads to different deformation mechanisms along the length scale...

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Autores principales:	Alexander Groetsch, Philippe K. Zysset, Peter Varga, Alexandra Pacureanu, Françoise Peyrin, Uwe Wolfram
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93e9f33886a7465686ef476328dee5bb
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spelling	oai:doaj.org-article:93e9f33886a7465686ef476328dee5bb2021-12-02T16:06:44ZAn experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale10.1038/s41598-021-93505-02045-2322https://doaj.org/article/93e9f33886a7465686ef476328dee5bb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93505-0https://doaj.org/toc/2045-2322Abstract Bone is an intriguingly complex material. It combines high strength, toughness and lightweight via an elaborate hierarchical structure. This structure results from a biologically driven self-assembly and self-organisation, and leads to different deformation mechanisms along the length scales. Characterising multiscale bone mechanics is fundamental to better understand these mechanisms including changes due to bone-related diseases. It also guides us in the design of new bio-inspired materials. A key-gap in understanding bone’s behaviour exists for its fundamental mechanical unit, the mineralised collagen fibre, a composite of organic collagen molecules and inorganic mineral nanocrystals. Here, we report an experimentally informed statistical elasto-plastic model to explain the fibre behaviour including the nanoscale interplay and load transfer with its main mechanical components. We utilise data from synchrotron nanoscale imaging, and combined micropillar compression and synchrotron X-ray scattering to develop the model. We see that a 10-15% micro- and nanomechanical heterogeneity in mechanical properties is essential to promote the ductile microscale behaviour preventing an abrupt overall failure even when individual fibrils have failed. We see that mineral particles take up 45% of strain compared to collagen molecules while interfibrillar shearing seems to enable the ductile post-yield behaviour. Our results suggest that a change in mineralisation and fibril-to-matrix interaction leads to different mechanical properties among mineralised tissues. Our model operates at crystalline-, molecular- and continuum-levels and sheds light on the micro- and nanoscale deformation of fibril-matrix reinforced composites.Alexander GroetschPhilippe K. ZyssetPeter VargaAlexandra PacureanuFrançoise PeyrinUwe WolframNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Groetsch Philippe K. Zysset Peter Varga Alexandra Pacureanu Françoise Peyrin Uwe Wolfram An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale
description	Abstract Bone is an intriguingly complex material. It combines high strength, toughness and lightweight via an elaborate hierarchical structure. This structure results from a biologically driven self-assembly and self-organisation, and leads to different deformation mechanisms along the length scales. Characterising multiscale bone mechanics is fundamental to better understand these mechanisms including changes due to bone-related diseases. It also guides us in the design of new bio-inspired materials. A key-gap in understanding bone’s behaviour exists for its fundamental mechanical unit, the mineralised collagen fibre, a composite of organic collagen molecules and inorganic mineral nanocrystals. Here, we report an experimentally informed statistical elasto-plastic model to explain the fibre behaviour including the nanoscale interplay and load transfer with its main mechanical components. We utilise data from synchrotron nanoscale imaging, and combined micropillar compression and synchrotron X-ray scattering to develop the model. We see that a 10-15% micro- and nanomechanical heterogeneity in mechanical properties is essential to promote the ductile microscale behaviour preventing an abrupt overall failure even when individual fibrils have failed. We see that mineral particles take up 45% of strain compared to collagen molecules while interfibrillar shearing seems to enable the ductile post-yield behaviour. Our results suggest that a change in mineralisation and fibril-to-matrix interaction leads to different mechanical properties among mineralised tissues. Our model operates at crystalline-, molecular- and continuum-levels and sheds light on the micro- and nanoscale deformation of fibril-matrix reinforced composites.
format	article
author	Alexander Groetsch Philippe K. Zysset Peter Varga Alexandra Pacureanu Françoise Peyrin Uwe Wolfram
author_facet	Alexander Groetsch Philippe K. Zysset Peter Varga Alexandra Pacureanu Françoise Peyrin Uwe Wolfram
author_sort	Alexander Groetsch
title	An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale
title_short	An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale
title_full	An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale
title_fullStr	An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale
title_full_unstemmed	An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale
title_sort	experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93e9f33886a7465686ef476328dee5bb
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An experimentally informed statistical elasto-plastic mineralised collagen fibre model at the micrometre and nanometre lengthscale

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