Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance

Cancer development is a multistep process in which cells must overcome a series of obstacles before they can become fully developed tumors. First, cells must develop the ability to proliferate unchecked. Once this is accomplished, they must be able to invade the neighboring tissue, as well as provid...

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Autores principales:	Antonia Piazzesi, Sumaiya Yasmeen Afsar, Gerhild vanEchten‐Deckert
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cancer ceramide gangliosides sphingolipid sphingosine kinase sphingosine‐1‐phosphate Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/93eae738db8f420db56ff9936ba96d43
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spelling	oai:doaj.org-article:93eae738db8f420db56ff9936ba96d432021-12-02T10:31:06ZSphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance1878-02611574-789110.1002/1878-0261.13063https://doaj.org/article/93eae738db8f420db56ff9936ba96d432021-12-01T00:00:00Zhttps://doi.org/10.1002/1878-0261.13063https://doaj.org/toc/1574-7891https://doaj.org/toc/1878-0261Cancer development is a multistep process in which cells must overcome a series of obstacles before they can become fully developed tumors. First, cells must develop the ability to proliferate unchecked. Once this is accomplished, they must be able to invade the neighboring tissue, as well as provide themselves with oxygen and nutrients. Finally, they must acquire the ability to detach from the newly formed mass in order to spread to other tissues, all the while evading an immune system that is primed for their destruction. Furthermore, increased levels of inflammation have been shown to be linked to the development of cancer, with sites of chronic inflammation being a common component of tumorigenic microenvironments. In this Review, we give an overview of the impact of sphingolipid metabolism in cancers, from initiation to metastatic dissemination, as well as discussing immune responses and resistance to treatments. We explore how sphingolipids can either help or hinder the progression of cells from a healthy phenotype to a cancerous one.Antonia PiazzesiSumaiya Yasmeen AfsarGerhild vanEchten‐DeckertWileyarticlecancerceramidegangliosidessphingolipidsphingosine kinasesphingosine‐1‐phosphateNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMolecular Oncology, Vol 15, Iss 12, Pp 3256-3279 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer ceramide gangliosides sphingolipid sphingosine kinase sphingosine‐1‐phosphate Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancer ceramide gangliosides sphingolipid sphingosine kinase sphingosine‐1‐phosphate Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Antonia Piazzesi Sumaiya Yasmeen Afsar Gerhild vanEchten‐Deckert Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance
description	Cancer development is a multistep process in which cells must overcome a series of obstacles before they can become fully developed tumors. First, cells must develop the ability to proliferate unchecked. Once this is accomplished, they must be able to invade the neighboring tissue, as well as provide themselves with oxygen and nutrients. Finally, they must acquire the ability to detach from the newly formed mass in order to spread to other tissues, all the while evading an immune system that is primed for their destruction. Furthermore, increased levels of inflammation have been shown to be linked to the development of cancer, with sites of chronic inflammation being a common component of tumorigenic microenvironments. In this Review, we give an overview of the impact of sphingolipid metabolism in cancers, from initiation to metastatic dissemination, as well as discussing immune responses and resistance to treatments. We explore how sphingolipids can either help or hinder the progression of cells from a healthy phenotype to a cancerous one.
format	article
author	Antonia Piazzesi Sumaiya Yasmeen Afsar Gerhild vanEchten‐Deckert
author_facet	Antonia Piazzesi Sumaiya Yasmeen Afsar Gerhild vanEchten‐Deckert
author_sort	Antonia Piazzesi
title	Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance
title_short	Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance
title_full	Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance
title_fullStr	Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance
title_full_unstemmed	Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance
title_sort	sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/93eae738db8f420db56ff9936ba96d43
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Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance

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