Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.

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Autores principales:	Zhen Wang, Lijian Xie, Guohui Ding, Sirui Song, Liqin Chen, Guang Li, Min Xia, Dingding Han, Yue Zheng, Jia Liu, Tingting Xiao, Hong Zhang, Yujuan Huang, Yixue Li, Min Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93ebaddff46c45799b701c2eb870db1f
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spelling	oai:doaj.org-article:93ebaddff46c45799b701c2eb870db1f2021-12-02T15:15:45ZSingle-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients10.1038/s41467-021-25771-52041-1723https://doaj.org/article/93ebaddff46c45799b701c2eb870db1f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25771-5https://doaj.org/toc/2041-1723Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.Zhen WangLijian XieGuohui DingSirui SongLiqin ChenGuang LiMin XiaDingding HanYue ZhengJia LiuTingting XiaoHong ZhangYujuan HuangYixue LiMin HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen Wang Lijian Xie Guohui Ding Sirui Song Liqin Chen Guang Li Min Xia Dingding Han Yue Zheng Jia Liu Tingting Xiao Hong Zhang Yujuan Huang Yixue Li Min Huang Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients
description	Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.
format	article
author	Zhen Wang Lijian Xie Guohui Ding Sirui Song Liqin Chen Guang Li Min Xia Dingding Han Yue Zheng Jia Liu Tingting Xiao Hong Zhang Yujuan Huang Yixue Li Min Huang
author_facet	Zhen Wang Lijian Xie Guohui Ding Sirui Song Liqin Chen Guang Li Min Xia Dingding Han Yue Zheng Jia Liu Tingting Xiao Hong Zhang Yujuan Huang Yixue Li Min Huang
author_sort	Zhen Wang
title	Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients
title_short	Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients
title_full	Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients
title_fullStr	Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients
title_full_unstemmed	Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients
title_sort	single-cell rna sequencing of peripheral blood mononuclear cells from acute kawasaki disease patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93ebaddff46c45799b701c2eb870db1f
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Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

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