Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats

Abstract Cisplatin (CP) is one of the most frequently used chemotherapy agents. The objective of this design was to determine the ameliorative effect of lycopene (LP) and/or N-acetylcysteine (NAC) in rats with hepatic and renal toxicity induced by CP. Rats were divided randomly into 7 groups (7 rats...

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Autores principales:	Asmaa Elsayed, Ashraf Elkomy, Reda Elkammar, Gehan Youssef, Ehab Yahya Abdelhiee, Walied Abdo, Sabreen Ezzat Fadl, Ahmed Soliman, Mohamed Aboubakr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93f4ba69411242e083ca436bf8d26a64
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spelling	oai:doaj.org-article:93f4ba69411242e083ca436bf8d26a642021-12-02T18:34:20ZSynergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats10.1038/s41598-021-93196-72045-2322https://doaj.org/article/93f4ba69411242e083ca436bf8d26a642021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93196-7https://doaj.org/toc/2045-2322Abstract Cisplatin (CP) is one of the most frequently used chemotherapy agents. The objective of this design was to determine the ameliorative effect of lycopene (LP) and/or N-acetylcysteine (NAC) in rats with hepatic and renal toxicity induced by CP. Rats were divided randomly into 7 groups (7 rats/group): control vehicle group (saline only), the LP group (10 mg/kg, orally), the NAC group (150 mg/kg, orally), the CP group (7.5 mg/kg, IP on day 27), the LP-CP group, the NAC-CP group, and the LP-NAC-CP group. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (APK), and levels of urea, creatinine, and lipids (cholesterol, triglycerides, and low-density lipoprotein-cholesterol) increased after CP injection in the serum. Moreover, CP decreased levels of protein, albumin, and HDL cholesterol. Meanwhile, malondialdehyde significantly increased with a decrease in reduced glutathione, superoxide dismutase, and catalase in the liver and kidney tissues. CP also induced some pathological lesions and increased the expression of caspase-3 in the liver and kidney tissues. Administration of LP and NAC alone or in combinations ameliorated hepatorenal toxicity and apoptosis induced by CP.Asmaa ElsayedAshraf ElkomyReda ElkammarGehan YoussefEhab Yahya AbdelhieeWalied AbdoSabreen Ezzat FadlAhmed SolimanMohamed AboubakrNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Asmaa Elsayed Ashraf Elkomy Reda Elkammar Gehan Youssef Ehab Yahya Abdelhiee Walied Abdo Sabreen Ezzat Fadl Ahmed Soliman Mohamed Aboubakr Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats
description	Abstract Cisplatin (CP) is one of the most frequently used chemotherapy agents. The objective of this design was to determine the ameliorative effect of lycopene (LP) and/or N-acetylcysteine (NAC) in rats with hepatic and renal toxicity induced by CP. Rats were divided randomly into 7 groups (7 rats/group): control vehicle group (saline only), the LP group (10 mg/kg, orally), the NAC group (150 mg/kg, orally), the CP group (7.5 mg/kg, IP on day 27), the LP-CP group, the NAC-CP group, and the LP-NAC-CP group. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (APK), and levels of urea, creatinine, and lipids (cholesterol, triglycerides, and low-density lipoprotein-cholesterol) increased after CP injection in the serum. Moreover, CP decreased levels of protein, albumin, and HDL cholesterol. Meanwhile, malondialdehyde significantly increased with a decrease in reduced glutathione, superoxide dismutase, and catalase in the liver and kidney tissues. CP also induced some pathological lesions and increased the expression of caspase-3 in the liver and kidney tissues. Administration of LP and NAC alone or in combinations ameliorated hepatorenal toxicity and apoptosis induced by CP.
format	article
author	Asmaa Elsayed Ashraf Elkomy Reda Elkammar Gehan Youssef Ehab Yahya Abdelhiee Walied Abdo Sabreen Ezzat Fadl Ahmed Soliman Mohamed Aboubakr
author_facet	Asmaa Elsayed Ashraf Elkomy Reda Elkammar Gehan Youssef Ehab Yahya Abdelhiee Walied Abdo Sabreen Ezzat Fadl Ahmed Soliman Mohamed Aboubakr
author_sort	Asmaa Elsayed
title	Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats
title_short	Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats
title_full	Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats
title_fullStr	Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats
title_full_unstemmed	Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats
title_sort	synergistic protective effects of lycopene and n-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93f4ba69411242e083ca436bf8d26a64
work_keys_str_mv	AT asmaaelsayed synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats AT ashrafelkomy synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats AT redaelkammar synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats AT gehanyoussef synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats AT ehabyahyaabdelhiee synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats AT waliedabdo synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats AT sabreenezzatfadl synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats AT ahmedsoliman synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats AT mohamedaboubakr synergisticprotectiveeffectsoflycopeneandnacetylcysteineagainstcisplatininducedhepatorenaltoxicityinrats
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Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats

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