Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis

Abstract Central nervous system (CNS) tumors are the most common solid tumors in children. Findings on the role of maternal and perinatal factors on the susceptibility or outcome of these tumors are inconclusive. Therefore, we investigated the association between these early-life factors, risk, and...

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Autores principales:	Maral Adel Fahmideh, Erin C. Peckham-Gregory, Jeremy M. Schraw, Murali Chintagumpala, Stephen C. Mack, Philip J. Lupo, Michael E. Scheurer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93f68e664e064a78ac2cb4d67923e098
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spelling	oai:doaj.org-article:93f68e664e064a78ac2cb4d67923e0982021-12-02T16:51:04ZMaternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis10.1038/s41598-021-88385-32045-2322https://doaj.org/article/93f68e664e064a78ac2cb4d67923e0982021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88385-3https://doaj.org/toc/2045-2322Abstract Central nervous system (CNS) tumors are the most common solid tumors in children. Findings on the role of maternal and perinatal factors on the susceptibility or outcome of these tumors are inconclusive. Therefore, we investigated the association between these early-life factors, risk, and survival of pediatric CNS tumors, using data from one of the world’s largest and most diverse cancer registries. Information on pediatric CNS tumor cases (n = 1950) for the period 1995–2011 was obtained from the Texas Cancer Registry. Birth certificate controls were frequency-matched on birth year at a ratio of 10:1 for the same period. Evaluated maternal and perinatal variables were obtained from birth records. Unconditional logistic regression was used to generate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for etiological factors. Additionally, Cox proportional hazards regression was employed to assess adjusted hazard ratios (HRs) and 95% CIs for survival factors. The results indicated that Hispanic and non-Hispanic black mothers were less likely to have children with CNS tumors compared to non-Hispanic white mothers (OR 0.88 [95% CI 0.78–0.98] P-value = 0.019; OR 0.79 [95% CI 0.67–0.93 P-value = 0.004], respectively). Infants born large for gestational age (OR 1.26 [95% CI 1.07–1.47] P-value = 0.004) and those delivered pre-term (OR 1.19 [95% CI 1.04–1.38] P-value = 0.013) showed an increased risk of CNS tumors. Infants born by vaginal forceps or vacuum delivery had a higher risk of CNS tumors compared to those born by spontaneous vaginal delivery (OR 1.35 [95% CI 1.12–1.62] P-value = 0.002). Additionally, offspring of Hispanic and non-Hispanic black mothers showed a higher risk of death (HR 1.45 [95% CI 1.16–1.80] P-value = 0.001; HR 1.53 [95% CI 1.12–2.09] P-value = 0.008, respectively). Infants born by cesarean had a higher risk of death compared to those delivered vaginally (HR 1.28 [95% CI 1.05–1.57] P-value = 0.016). These findings indicate the important role of maternal and perinatal characteristics in the etiology and survival of these clinically significant malignancies.Maral Adel FahmidehErin C. Peckham-GregoryJeremy M. SchrawMurali ChintagumpalaStephen C. MackPhilip J. LupoMichael E. ScheurerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maral Adel Fahmideh Erin C. Peckham-Gregory Jeremy M. Schraw Murali Chintagumpala Stephen C. Mack Philip J. Lupo Michael E. Scheurer Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis
description	Abstract Central nervous system (CNS) tumors are the most common solid tumors in children. Findings on the role of maternal and perinatal factors on the susceptibility or outcome of these tumors are inconclusive. Therefore, we investigated the association between these early-life factors, risk, and survival of pediatric CNS tumors, using data from one of the world’s largest and most diverse cancer registries. Information on pediatric CNS tumor cases (n = 1950) for the period 1995–2011 was obtained from the Texas Cancer Registry. Birth certificate controls were frequency-matched on birth year at a ratio of 10:1 for the same period. Evaluated maternal and perinatal variables were obtained from birth records. Unconditional logistic regression was used to generate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for etiological factors. Additionally, Cox proportional hazards regression was employed to assess adjusted hazard ratios (HRs) and 95% CIs for survival factors. The results indicated that Hispanic and non-Hispanic black mothers were less likely to have children with CNS tumors compared to non-Hispanic white mothers (OR 0.88 [95% CI 0.78–0.98] P-value = 0.019; OR 0.79 [95% CI 0.67–0.93 P-value = 0.004], respectively). Infants born large for gestational age (OR 1.26 [95% CI 1.07–1.47] P-value = 0.004) and those delivered pre-term (OR 1.19 [95% CI 1.04–1.38] P-value = 0.013) showed an increased risk of CNS tumors. Infants born by vaginal forceps or vacuum delivery had a higher risk of CNS tumors compared to those born by spontaneous vaginal delivery (OR 1.35 [95% CI 1.12–1.62] P-value = 0.002). Additionally, offspring of Hispanic and non-Hispanic black mothers showed a higher risk of death (HR 1.45 [95% CI 1.16–1.80] P-value = 0.001; HR 1.53 [95% CI 1.12–2.09] P-value = 0.008, respectively). Infants born by cesarean had a higher risk of death compared to those delivered vaginally (HR 1.28 [95% CI 1.05–1.57] P-value = 0.016). These findings indicate the important role of maternal and perinatal characteristics in the etiology and survival of these clinically significant malignancies.
format	article
author	Maral Adel Fahmideh Erin C. Peckham-Gregory Jeremy M. Schraw Murali Chintagumpala Stephen C. Mack Philip J. Lupo Michael E. Scheurer
author_facet	Maral Adel Fahmideh Erin C. Peckham-Gregory Jeremy M. Schraw Murali Chintagumpala Stephen C. Mack Philip J. Lupo Michael E. Scheurer
author_sort	Maral Adel Fahmideh
title	Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis
title_short	Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis
title_full	Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis
title_fullStr	Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis
title_full_unstemmed	Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis
title_sort	maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93f68e664e064a78ac2cb4d67923e098
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Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis

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