A Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report

Amel Awad Ibn Idris Rodwan,1 Osama Khder Ahmed Elmansour,1,2 Amar F Eldow Ahmed,3 Elnour Mohammed Elagib,1,4 Noha Ibrahim Ahmed Eltahir,4,5 Abubaker Hassan,6 Sara M El-Sadig,7 Abdel Gaffar Abdel Allah Mohammed,8 Huyam H Awadalla,9 Abubakr Abdalwahab Mohammed,5 Mohammed Elmujtba Adam Essa6,10 1Depart...

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Autores principales:	Ibn Idris Rodwan AA, Ahmed Elmansour OK, Ahmed AFE, Elagib EM, Ahmed Eltahir NI, Hassan A, El-Sadig SM, Mohammed AGAA, Awadalla HH, Mohammed AA, Adam Essa ME
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ttp sle african female rituximab and plasmapheresis. Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/93f7e6c858854d1a8c220a4c2e9fb8f8
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spelling	oai:doaj.org-article:93f7e6c858854d1a8c220a4c2e9fb8f82021-11-07T18:42:57ZA Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report1179-2736https://doaj.org/article/93f7e6c858854d1a8c220a4c2e9fb8f82021-11-01T00:00:00Zhttps://www.dovepress.com/a-rare-association-of-thrombotic-thrombocytopenic-purpura-with-systemi-peer-reviewed-fulltext-article-JBMhttps://doaj.org/toc/1179-2736Amel Awad Ibn Idris Rodwan,1 Osama Khder Ahmed Elmansour,1,2 Amar F Eldow Ahmed,3 Elnour Mohammed Elagib,1,4 Noha Ibrahim Ahmed Eltahir,4,5 Abubaker Hassan,6 Sara M El-Sadig,7 Abdel Gaffar Abdel Allah Mohammed,8 Huyam H Awadalla,9 Abubakr Abdalwahab Mohammed,5 Mohammed Elmujtba Adam Essa6,10 1Department of Rheumatology, Sudan Medical Specialization Council, Khartoum, Sudan; 2Department of Rheumatology, Faculty of Medicine, Shendi University, Shendi, Sudan; 3Department of Internal Medicine, Wayne State University, Detroit, MI, USA; 4Department of Rheumatology, Omdurman Military Hospital, Khartoum, Sudan; 5Department of Medicine, Faculty of Medicine, Karary University, Khartoum, Sudan; 6Department of Clinical Medicine, Medical and Cancer Research Institute, Nyala, Sudan; 7Department of Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan; 8Rheumatology Department, Security Forces Hospital, Makkah, Saudi Arabia; 9Department of Internal Medicine, Detroit Medical Centre, Detroit, MI, USA; 10Faculty of Medicine, Al Fashir University, Al Fashir, SudanCorrespondence: Mohammed Elmujtba Adam EssaDepartment of Clinical Medicine, Medical and Cancer Research Institute, Nyala, SudanTel +249-90-700-938Email Awadali818@yahoo.comAbstract: Thrombotic thrombocytopenic purpura (TTP) is an uncommon life-threatening condition characterized by hemolytic disorders. The coexistence of systemic lupus erythematosus (SLE) with TTP is extremely rare, although Africans are at increased risk due to inherited risk factors. This report describes a rare clinical manifestation of TTP associated with SLE in a Sudanese patient. A 41-year-old Sudanese woman presented to the emergency department with symptoms and features that were suggestive of malaria, for which she had been treated accordingly. However, a few days later she complained of fever, and was found to have a body temperature of 39.5°C, jaundice, anemia, and thrombocytopenia. Soon after admission, she developed confusion and unrecordable blood pressure. After the patient had stabilized, clinical assessment, immune-system investigation (antinuclear antibody profile, complements, blood panel), and imaging revealed a diagnosis of TTP associated with SLE. The patient received imipenem 500 mg, five sessions of plasmapheresis (60 mL/kg), methylprednisolone 1 g pulse for 3 days, and rituximab 375 mg/week. Three weeks later, the patient was discharged after her condition had improved, and she is now on regular follow-up.Keywords: TTP, SLE, African female, rituximab and plasmapheresisIbn Idris Rodwan AAAhmed Elmansour OKAhmed AFEElagib EMAhmed Eltahir NIHassan AEl-Sadig SMMohammed AGAAAwadalla HHMohammed AAAdam Essa MEDove Medical Pressarticlettpsleafrican femalerituximab and plasmapheresis.Diseases of the blood and blood-forming organsRC633-647.5ENJournal of Blood Medicine, Vol Volume 12, Pp 945-949 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ttp sle african female rituximab and plasmapheresis. Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	ttp sle african female rituximab and plasmapheresis. Diseases of the blood and blood-forming organs RC633-647.5 Ibn Idris Rodwan AA Ahmed Elmansour OK Ahmed AFE Elagib EM Ahmed Eltahir NI Hassan A El-Sadig SM Mohammed AGAA Awadalla HH Mohammed AA Adam Essa ME A Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report
description	Amel Awad Ibn Idris Rodwan,1 Osama Khder Ahmed Elmansour,1,2 Amar F Eldow Ahmed,3 Elnour Mohammed Elagib,1,4 Noha Ibrahim Ahmed Eltahir,4,5 Abubaker Hassan,6 Sara M El-Sadig,7 Abdel Gaffar Abdel Allah Mohammed,8 Huyam H Awadalla,9 Abubakr Abdalwahab Mohammed,5 Mohammed Elmujtba Adam Essa6,10 1Department of Rheumatology, Sudan Medical Specialization Council, Khartoum, Sudan; 2Department of Rheumatology, Faculty of Medicine, Shendi University, Shendi, Sudan; 3Department of Internal Medicine, Wayne State University, Detroit, MI, USA; 4Department of Rheumatology, Omdurman Military Hospital, Khartoum, Sudan; 5Department of Medicine, Faculty of Medicine, Karary University, Khartoum, Sudan; 6Department of Clinical Medicine, Medical and Cancer Research Institute, Nyala, Sudan; 7Department of Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan; 8Rheumatology Department, Security Forces Hospital, Makkah, Saudi Arabia; 9Department of Internal Medicine, Detroit Medical Centre, Detroit, MI, USA; 10Faculty of Medicine, Al Fashir University, Al Fashir, SudanCorrespondence: Mohammed Elmujtba Adam EssaDepartment of Clinical Medicine, Medical and Cancer Research Institute, Nyala, SudanTel +249-90-700-938Email Awadali818@yahoo.comAbstract: Thrombotic thrombocytopenic purpura (TTP) is an uncommon life-threatening condition characterized by hemolytic disorders. The coexistence of systemic lupus erythematosus (SLE) with TTP is extremely rare, although Africans are at increased risk due to inherited risk factors. This report describes a rare clinical manifestation of TTP associated with SLE in a Sudanese patient. A 41-year-old Sudanese woman presented to the emergency department with symptoms and features that were suggestive of malaria, for which she had been treated accordingly. However, a few days later she complained of fever, and was found to have a body temperature of 39.5°C, jaundice, anemia, and thrombocytopenia. Soon after admission, she developed confusion and unrecordable blood pressure. After the patient had stabilized, clinical assessment, immune-system investigation (antinuclear antibody profile, complements, blood panel), and imaging revealed a diagnosis of TTP associated with SLE. The patient received imipenem 500 mg, five sessions of plasmapheresis (60 mL/kg), methylprednisolone 1 g pulse for 3 days, and rituximab 375 mg/week. Three weeks later, the patient was discharged after her condition had improved, and she is now on regular follow-up.Keywords: TTP, SLE, African female, rituximab and plasmapheresis
format	article
author	Ibn Idris Rodwan AA Ahmed Elmansour OK Ahmed AFE Elagib EM Ahmed Eltahir NI Hassan A El-Sadig SM Mohammed AGAA Awadalla HH Mohammed AA Adam Essa ME
author_facet	Ibn Idris Rodwan AA Ahmed Elmansour OK Ahmed AFE Elagib EM Ahmed Eltahir NI Hassan A El-Sadig SM Mohammed AGAA Awadalla HH Mohammed AA Adam Essa ME
author_sort	Ibn Idris Rodwan AA
title	A Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report
title_short	A Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report
title_full	A Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report
title_fullStr	A Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report
title_full_unstemmed	A Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report
title_sort	rare association of thrombotic thrombocytopenic purpura with systemic lupus erythematosus in a sudanese woman: case report
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/93f7e6c858854d1a8c220a4c2e9fb8f8
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A Rare Association of Thrombotic Thrombocytopenic Purpura with Systemic Lupus Erythematosus in a Sudanese Woman: Case Report

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