Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression

LKB1 regulates various cellular processes such as cell proliferation, energy homeostasis and cell polarity and is frequently downregulated in various tumours. Here the authors show that LKB1 activation requires direct binding to phospholipids and show this has an implication for carcinogenesis.

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Autores principales:	Giada Dogliotti, Lars Kullmann, Pratibha Dhumale, Christian Thiele, Olga Panichkina, Gudrun Mendl, Roland Houben, Sebastian Haferkamp, Andreas W. Püschel, Michael P. Krahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93f85e172ac9493897b09df8f487de33
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spelling	oai:doaj.org-article:93f85e172ac9493897b09df8f487de332021-12-02T17:06:08ZMembrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression10.1038/ncomms157472041-1723https://doaj.org/article/93f85e172ac9493897b09df8f487de332017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15747https://doaj.org/toc/2041-1723LKB1 regulates various cellular processes such as cell proliferation, energy homeostasis and cell polarity and is frequently downregulated in various tumours. Here the authors show that LKB1 activation requires direct binding to phospholipids and show this has an implication for carcinogenesis.Giada DogliottiLars KullmannPratibha DhumaleChristian ThieleOlga PanichkinaGudrun MendlRoland HoubenSebastian HaferkampAndreas W. PüschelMichael P. KrahnNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giada Dogliotti Lars Kullmann Pratibha Dhumale Christian Thiele Olga Panichkina Gudrun Mendl Roland Houben Sebastian Haferkamp Andreas W. Püschel Michael P. Krahn Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
description	LKB1 regulates various cellular processes such as cell proliferation, energy homeostasis and cell polarity and is frequently downregulated in various tumours. Here the authors show that LKB1 activation requires direct binding to phospholipids and show this has an implication for carcinogenesis.
format	article
author	Giada Dogliotti Lars Kullmann Pratibha Dhumale Christian Thiele Olga Panichkina Gudrun Mendl Roland Houben Sebastian Haferkamp Andreas W. Püschel Michael P. Krahn
author_facet	Giada Dogliotti Lars Kullmann Pratibha Dhumale Christian Thiele Olga Panichkina Gudrun Mendl Roland Houben Sebastian Haferkamp Andreas W. Püschel Michael P. Krahn
author_sort	Giada Dogliotti
title	Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
title_short	Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
title_full	Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
title_fullStr	Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
title_full_unstemmed	Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
title_sort	membrane-binding and activation of lkb1 by phosphatidic acid is essential for development and tumour suppression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/93f85e172ac9493897b09df8f487de33
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Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression

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