Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives

1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction between isoquinolines and 2-naphthols to effi...

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Autores principales:	Peng-Ying Jiang, Kai-Fang Fan, Shaoyu Li, Shao-Hua Xiang, Bin Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/93f9dd3539eb426fb76788c1596d48ac
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spelling	oai:doaj.org-article:93f9dd3539eb426fb76788c1596d48ac2021-12-02T16:45:14ZMetal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives10.1038/s41467-021-22621-22041-1723https://doaj.org/article/93f9dd3539eb426fb76788c1596d48ac2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22621-2https://doaj.org/toc/2041-17231-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction between isoquinolines and 2-naphthols to efficiently access the QUINOL scaffolds in a metal-free manner.Peng-Ying JiangKai-Fang FanShaoyu LiShao-Hua XiangBin TanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng-Ying Jiang Kai-Fang Fan Shaoyu Li Shao-Hua Xiang Bin Tan Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives
description	1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction between isoquinolines and 2-naphthols to efficiently access the QUINOL scaffolds in a metal-free manner.
format	article
author	Peng-Ying Jiang Kai-Fang Fan Shaoyu Li Shao-Hua Xiang Bin Tan
author_facet	Peng-Ying Jiang Kai-Fang Fan Shaoyu Li Shao-Hua Xiang Bin Tan
author_sort	Peng-Ying Jiang
title	Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives
title_short	Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives
title_full	Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives
title_fullStr	Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives
title_full_unstemmed	Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives
title_sort	metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric quinol and its derivatives
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/93f9dd3539eb426fb76788c1596d48ac
work_keys_str_mv	AT pengyingjiang metalfreeoxidativecrosscouplingenabledpracticalsynthesisofatropisomericquinolanditsderivatives AT kaifangfan metalfreeoxidativecrosscouplingenabledpracticalsynthesisofatropisomericquinolanditsderivatives AT shaoyuli metalfreeoxidativecrosscouplingenabledpracticalsynthesisofatropisomericquinolanditsderivatives AT shaohuaxiang metalfreeoxidativecrosscouplingenabledpracticalsynthesisofatropisomericquinolanditsderivatives AT bintan metalfreeoxidativecrosscouplingenabledpracticalsynthesisofatropisomericquinolanditsderivatives
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Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives

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