Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives

1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction between isoquinolines and 2-naphthols to effi...

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Bibliographic Details
Main Authors: Peng-Ying Jiang, Kai-Fang Fan, Shaoyu Li, Shao-Hua Xiang, Bin Tan
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Q
Online Access:https://doaj.org/article/93f9dd3539eb426fb76788c1596d48ac
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