Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog

A 16-year-old spayed female Pomeranian dog was presented to the hospital with an acute onset of pain and non-weight-bearing lameness in the right forelimb. On physical examination, knuckling, coolness, pain, and cyanosis were observed in the affected forelimb. Peripheral blood glucose concentration...

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Autores principales:	Tae-Yoon Eom, Ju-Won Choi, Kyong-Ah Yoon, Soon-Wuk Jeong, Jung-Hyun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	arterial thrombosis dog forelimb ataxia hyperadrenocorticism non-traumatic thromboelastography Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/93f9fa0fd60c463c85c8d5a81efa9b94
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spelling	oai:doaj.org-article:93f9fa0fd60c463c85c8d5a81efa9b942021-12-01T01:21:59ZCase Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog2297-176910.3389/fvets.2021.795928https://doaj.org/article/93f9fa0fd60c463c85c8d5a81efa9b942021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.795928/fullhttps://doaj.org/toc/2297-1769A 16-year-old spayed female Pomeranian dog was presented to the hospital with an acute onset of pain and non-weight-bearing lameness in the right forelimb. On physical examination, knuckling, coolness, pain, and cyanosis were observed in the affected forelimb. Peripheral blood glucose concentration and body surface temperature differed between the right and left forelimbs. Hypercoagulable thromboelastographic results and increased D-dimer levels were suggestive of thrombus. Accordingly, recombinant tissue plasminogen activator (rtPA) was administered intravenously. Prompt clinical improvements (including restored warmth of the affected limb) occurred, and rtPA was discontinued after two shots administered 2 h apart owing to concerns of bleeding side effects. The dog was discharged 6 days after admission, and outpatient treatment with clopidogrel was continued for the prevention of re-thrombosis. Following patient stabilization, further examinations for underlying diseases of hypercoagulability were conducted; hyperadrenocorticism (HAC) was diagnosed, and oral trilostane therapy was thus administered. Eight weeks later, the patient regained normal mobility. Finally, in the present canine patient with arterial thrombosis, thrombolysis with rtPA successfully improved clinical symptoms and the following administration of clopidogrel inhibited the formation of additional thrombus.Tae-Yoon EomJu-Won ChoiKyong-Ah YoonSoon-Wuk JeongJung-Hyun KimFrontiers Media S.A.articlearterial thrombosisdogforelimb ataxiahyperadrenocorticismnon-traumaticthromboelastographyVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial thrombosis dog forelimb ataxia hyperadrenocorticism non-traumatic thromboelastography Veterinary medicine SF600-1100
spellingShingle	arterial thrombosis dog forelimb ataxia hyperadrenocorticism non-traumatic thromboelastography Veterinary medicine SF600-1100 Tae-Yoon Eom Ju-Won Choi Kyong-Ah Yoon Soon-Wuk Jeong Jung-Hyun Kim Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog
description	A 16-year-old spayed female Pomeranian dog was presented to the hospital with an acute onset of pain and non-weight-bearing lameness in the right forelimb. On physical examination, knuckling, coolness, pain, and cyanosis were observed in the affected forelimb. Peripheral blood glucose concentration and body surface temperature differed between the right and left forelimbs. Hypercoagulable thromboelastographic results and increased D-dimer levels were suggestive of thrombus. Accordingly, recombinant tissue plasminogen activator (rtPA) was administered intravenously. Prompt clinical improvements (including restored warmth of the affected limb) occurred, and rtPA was discontinued after two shots administered 2 h apart owing to concerns of bleeding side effects. The dog was discharged 6 days after admission, and outpatient treatment with clopidogrel was continued for the prevention of re-thrombosis. Following patient stabilization, further examinations for underlying diseases of hypercoagulability were conducted; hyperadrenocorticism (HAC) was diagnosed, and oral trilostane therapy was thus administered. Eight weeks later, the patient regained normal mobility. Finally, in the present canine patient with arterial thrombosis, thrombolysis with rtPA successfully improved clinical symptoms and the following administration of clopidogrel inhibited the formation of additional thrombus.
format	article
author	Tae-Yoon Eom Ju-Won Choi Kyong-Ah Yoon Soon-Wuk Jeong Jung-Hyun Kim
author_facet	Tae-Yoon Eom Ju-Won Choi Kyong-Ah Yoon Soon-Wuk Jeong Jung-Hyun Kim
author_sort	Tae-Yoon Eom
title	Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog
title_short	Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog
title_full	Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog
title_fullStr	Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog
title_full_unstemmed	Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog
title_sort	case report: non-traumatic unilateral forelimb arterial thrombosis associated with hyperadrenocorticism in a dog
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/93f9fa0fd60c463c85c8d5a81efa9b94
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Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog

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