Circadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia
Background: Labor pain perception has been demonstrated to exhibit a circadian rhythm with lower pain scores during the day compared with the night. This study aimed to determine and compare the median effective dose (ED50) of ropivacaine in parturients having epidural labor analgesia during the day...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:93fb08775c8340e38425c276d94c28662021-11-18T05:53:26ZCircadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia2296-858X10.3389/fmed.2021.669264https://doaj.org/article/93fb08775c8340e38425c276d94c28662021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.669264/fullhttps://doaj.org/toc/2296-858XBackground: Labor pain perception has been demonstrated to exhibit a circadian rhythm with lower pain scores during the day compared with the night. This study aimed to determine and compare the median effective dose (ED50) of ropivacaine in parturients having epidural labor analgesia during the day vs. during the night.Methods: The study group consisted of 60 nulliparous healthy parturients who were assigned to one of two groups according to the time they requested labor analgesia: Day Group (7:01 am to 7:00 pm) and Night Group (7:01 pm to 7:00 am). A bolus of.15% ropivacaine was administered epidurally and effective analgesia was defined as the attainment of a visual analog scale (VAS) pain score ≤ 10 mm within 30 min. The dose of ropivacaine for the first parturient in each group was 18 mg. The dose for each subsequent parturient was varied with increments or decrements of 3 mg based on the response of the previous subject. The ED50 was calculated using up-down sequential analysis. Probit regression was used to estimate the relative mean potency of ropivacaine between groups.Results: The ED50 (mean [95% CI]) of ropivacaine was lower in the Day Group (17.9 [16.5–19.4] mg) than in the Night Group (20.9 [19.2–22.7] mg) (P = 0.003). The estimate of relative potency for ropivacaine for the Night Group vs. the Day Group was 0.85 (95% CI:0.56–0.98).Conclusions: Under the conditions of this study, the dose requirement for epidural ropivacaine for labor analgesia was ~ 15% greater during the night than during the day.Clinical Trials Registration: Chinese Clinical Trial Registry (No.: ChiCTR1900025269. http://www.chictr.org.cn/showprojen.aspx?proj=36993).Jiali DengJiali DengChangna WeiChangna WeiLin LiuJing QianFei XiaoFei XiaoXinzhong ChenFrontiers Media S.A.articlechronobiologycircadian rhythmdose-responseepidural analgesialabor analgesiaropivacaineMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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DOAJ |
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DOAJ |
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| topic |
chronobiology circadian rhythm dose-response epidural analgesia labor analgesia ropivacaine Medicine (General) R5-920 |
| spellingShingle |
chronobiology circadian rhythm dose-response epidural analgesia labor analgesia ropivacaine Medicine (General) R5-920 Jiali Deng Jiali Deng Changna Wei Changna Wei Lin Liu Jing Qian Fei Xiao Fei Xiao Xinzhong Chen Circadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia |
| description |
Background: Labor pain perception has been demonstrated to exhibit a circadian rhythm with lower pain scores during the day compared with the night. This study aimed to determine and compare the median effective dose (ED50) of ropivacaine in parturients having epidural labor analgesia during the day vs. during the night.Methods: The study group consisted of 60 nulliparous healthy parturients who were assigned to one of two groups according to the time they requested labor analgesia: Day Group (7:01 am to 7:00 pm) and Night Group (7:01 pm to 7:00 am). A bolus of.15% ropivacaine was administered epidurally and effective analgesia was defined as the attainment of a visual analog scale (VAS) pain score ≤ 10 mm within 30 min. The dose of ropivacaine for the first parturient in each group was 18 mg. The dose for each subsequent parturient was varied with increments or decrements of 3 mg based on the response of the previous subject. The ED50 was calculated using up-down sequential analysis. Probit regression was used to estimate the relative mean potency of ropivacaine between groups.Results: The ED50 (mean [95% CI]) of ropivacaine was lower in the Day Group (17.9 [16.5–19.4] mg) than in the Night Group (20.9 [19.2–22.7] mg) (P = 0.003). The estimate of relative potency for ropivacaine for the Night Group vs. the Day Group was 0.85 (95% CI:0.56–0.98).Conclusions: Under the conditions of this study, the dose requirement for epidural ropivacaine for labor analgesia was ~ 15% greater during the night than during the day.Clinical Trials Registration: Chinese Clinical Trial Registry (No.: ChiCTR1900025269. http://www.chictr.org.cn/showprojen.aspx?proj=36993). |
| format |
article |
| author |
Jiali Deng Jiali Deng Changna Wei Changna Wei Lin Liu Jing Qian Fei Xiao Fei Xiao Xinzhong Chen |
| author_facet |
Jiali Deng Jiali Deng Changna Wei Changna Wei Lin Liu Jing Qian Fei Xiao Fei Xiao Xinzhong Chen |
| author_sort |
Jiali Deng |
| title |
Circadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia |
| title_short |
Circadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia |
| title_full |
Circadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia |
| title_fullStr |
Circadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia |
| title_full_unstemmed |
Circadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia |
| title_sort |
circadian variation in the median effective dose of epidural ropivacaine for labor analgesia |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/93fb08775c8340e38425c276d94c2866 |
| work_keys_str_mv |
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