A Novel Cell Morphology Analyzer Application in Head and Neck Cancer

Yongli Zhang,1,2 Mengyao Xie,1,2 Ruoyan Xue,1,2 Qi Tang,1,2 Xiaohui Zhu,1,2 Jian Wang,1,2 Hua Yang,1,2 Chao Ma3– 5 1Department of Otolaryngology, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, 100730, People’s Republic of China;...

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Autores principales:	Zhang Y, Xie M, Xue R, Tang Q, Zhu X, Wang J, Yang H, Ma C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	the divescope cell morphology analyzer head and neck cancer resection margins pathological diagnosis. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/93fbde95795141738574832827e6f80d
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spelling	oai:doaj.org-article:93fbde95795141738574832827e6f80d2021-12-02T19:17:36ZA Novel Cell Morphology Analyzer Application in Head and Neck Cancer1178-7074https://doaj.org/article/93fbde95795141738574832827e6f80d2021-12-01T00:00:00Zhttps://www.dovepress.com/a-novel-cell-morphology-analyzer-application-in-head-and-neck-cancer-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Yongli Zhang,1,2 Mengyao Xie,1,2 Ruoyan Xue,1,2 Qi Tang,1,2 Xiaohui Zhu,1,2 Jian Wang,1,2 Hua Yang,1,2 Chao Ma3– 5 1Department of Otolaryngology, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, 100730, People’s Republic of China; 2Translational Medicine Center, Peking Union Medical College Hospital, Beijing, 100730, People’s Republic of China; 3Institute of Basic Medical Sciences, Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, People’s Republic of China; 4Joint Laboratory of Anesthesia and Pain, Peking Union Medical College, Beijing, 100730, People’s Republic of China; 5Chinese Institute for Brain Research, Beijing, 102206, People’s Republic of ChinaCorrespondence: Jian Wang; Hua YangDepartment of Otolaryngology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, People’s Republic of ChinaTel +86 13673164261; +86 13701127757Fax +86-10-69156311Email wangjianent@163.com; dr_yanghua2021@163.comPurpose: Rapid and accurate diagnosis of the pathological characteristics of head and neck cancer and tumor resection margins is important. The DiveScope cell morphology analyzer (DiveScope) is a new endomicroscope that can rapidly image living tissues and cells. In this study, we preliminarily examined the accuracy of the DiveScope for determining the malignancy of head and neck cancers and the positivity/negativity of tumor resection margins and determined the consistency between diagnostic results with the DiveScope and those of frozen section pathology to provide a foundation for further clinical trials in pathological diagnosis of head and neck cancers and tumor resection margins.Methods: Head and neck cancer samples and resection margin samples were rapidly stained ex vivo before observation under the DiveScope cell morphology analyzer. Experienced pathologists distinguished the benignity and malignancy of the tumors based on images obtained by the DiveScope in a double-blind manner to validate the diagnostic performance of the analyzer.Results: We found that the cell morphology, cell nucleus morphology, karyoplasmic ratio, and even the nucleolus could be clearly distinguished. The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of benign and malignant head and neck cancer according to DiveScope results were 10.55 and 0.04, respectively. The PLR and NLR of the head and neck cancer resection margins according to the DiveScope were 19.01 and 0, respectively.Conclusion: The DiveScope showed high accuracy in determining the benignity and malignancy of head and neck cancer and the positivity/negativity of resection margins, and its results were highly consistent with those of intraoperative frozen section pathology tests.Keywords: the DiveScope cell morphology analyzer, head and neck cancer, resection margins, pathological diagnosisZhang YXie MXue RTang QZhu XWang JYang HMa CDove Medical Pressarticlethe divescope cell morphology analyzerhead and neck cancerresection marginspathological diagnosis.Medicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 9307-9314 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	the divescope cell morphology analyzer head and neck cancer resection margins pathological diagnosis. Medicine (General) R5-920
spellingShingle	the divescope cell morphology analyzer head and neck cancer resection margins pathological diagnosis. Medicine (General) R5-920 Zhang Y Xie M Xue R Tang Q Zhu X Wang J Yang H Ma C A Novel Cell Morphology Analyzer Application in Head and Neck Cancer
description	Yongli Zhang,1,2 Mengyao Xie,1,2 Ruoyan Xue,1,2 Qi Tang,1,2 Xiaohui Zhu,1,2 Jian Wang,1,2 Hua Yang,1,2 Chao Ma3– 5 1Department of Otolaryngology, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, 100730, People’s Republic of China; 2Translational Medicine Center, Peking Union Medical College Hospital, Beijing, 100730, People’s Republic of China; 3Institute of Basic Medical Sciences, Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, People’s Republic of China; 4Joint Laboratory of Anesthesia and Pain, Peking Union Medical College, Beijing, 100730, People’s Republic of China; 5Chinese Institute for Brain Research, Beijing, 102206, People’s Republic of ChinaCorrespondence: Jian Wang; Hua YangDepartment of Otolaryngology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, People’s Republic of ChinaTel +86 13673164261; +86 13701127757Fax +86-10-69156311Email wangjianent@163.com; dr_yanghua2021@163.comPurpose: Rapid and accurate diagnosis of the pathological characteristics of head and neck cancer and tumor resection margins is important. The DiveScope cell morphology analyzer (DiveScope) is a new endomicroscope that can rapidly image living tissues and cells. In this study, we preliminarily examined the accuracy of the DiveScope for determining the malignancy of head and neck cancers and the positivity/negativity of tumor resection margins and determined the consistency between diagnostic results with the DiveScope and those of frozen section pathology to provide a foundation for further clinical trials in pathological diagnosis of head and neck cancers and tumor resection margins.Methods: Head and neck cancer samples and resection margin samples were rapidly stained ex vivo before observation under the DiveScope cell morphology analyzer. Experienced pathologists distinguished the benignity and malignancy of the tumors based on images obtained by the DiveScope in a double-blind manner to validate the diagnostic performance of the analyzer.Results: We found that the cell morphology, cell nucleus morphology, karyoplasmic ratio, and even the nucleolus could be clearly distinguished. The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of benign and malignant head and neck cancer according to DiveScope results were 10.55 and 0.04, respectively. The PLR and NLR of the head and neck cancer resection margins according to the DiveScope were 19.01 and 0, respectively.Conclusion: The DiveScope showed high accuracy in determining the benignity and malignancy of head and neck cancer and the positivity/negativity of resection margins, and its results were highly consistent with those of intraoperative frozen section pathology tests.Keywords: the DiveScope cell morphology analyzer, head and neck cancer, resection margins, pathological diagnosis
format	article
author	Zhang Y Xie M Xue R Tang Q Zhu X Wang J Yang H Ma C
author_facet	Zhang Y Xie M Xue R Tang Q Zhu X Wang J Yang H Ma C
author_sort	Zhang Y
title	A Novel Cell Morphology Analyzer Application in Head and Neck Cancer
title_short	A Novel Cell Morphology Analyzer Application in Head and Neck Cancer
title_full	A Novel Cell Morphology Analyzer Application in Head and Neck Cancer
title_fullStr	A Novel Cell Morphology Analyzer Application in Head and Neck Cancer
title_full_unstemmed	A Novel Cell Morphology Analyzer Application in Head and Neck Cancer
title_sort	novel cell morphology analyzer application in head and neck cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/93fbde95795141738574832827e6f80d
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A Novel Cell Morphology Analyzer Application in Head and Neck Cancer

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