Structural basis of neurosteroid anesthetic action on GABAA receptors

The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the d...

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Auteurs principaux:	Qiang Chen, Marta M. Wells, Palaniappa Arjunan, Tommy S. Tillman, Aina E. Cohen, Yan Xu, Pei Tang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/93fc7086c93940d39f5324fda014b220
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spelling	oai:doaj.org-article:93fc7086c93940d39f5324fda014b2202021-12-02T15:34:37ZStructural basis of neurosteroid anesthetic action on GABAA receptors10.1038/s41467-018-06361-42041-1723https://doaj.org/article/93fc7086c93940d39f5324fda014b2202018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06361-4https://doaj.org/toc/2041-1723The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the development of new GABAAR modulators.Qiang ChenMarta M. WellsPalaniappa ArjunanTommy S. TillmanAina E. CohenYan XuPei TangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiang Chen Marta M. Wells Palaniappa Arjunan Tommy S. Tillman Aina E. Cohen Yan Xu Pei Tang Structural basis of neurosteroid anesthetic action on GABAA receptors
description	The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the development of new GABAAR modulators.
format	article
author	Qiang Chen Marta M. Wells Palaniappa Arjunan Tommy S. Tillman Aina E. Cohen Yan Xu Pei Tang
author_facet	Qiang Chen Marta M. Wells Palaniappa Arjunan Tommy S. Tillman Aina E. Cohen Yan Xu Pei Tang
author_sort	Qiang Chen
title	Structural basis of neurosteroid anesthetic action on GABAA receptors
title_short	Structural basis of neurosteroid anesthetic action on GABAA receptors
title_full	Structural basis of neurosteroid anesthetic action on GABAA receptors
title_fullStr	Structural basis of neurosteroid anesthetic action on GABAA receptors
title_full_unstemmed	Structural basis of neurosteroid anesthetic action on GABAA receptors
title_sort	structural basis of neurosteroid anesthetic action on gabaa receptors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/93fc7086c93940d39f5324fda014b220
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_version_	1718386793764618240

Structural basis of neurosteroid anesthetic action on GABAA receptors

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