Structural basis of neurosteroid anesthetic action on GABAA receptors

The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the d...

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Autores principales: Qiang Chen, Marta M. Wells, Palaniappa Arjunan, Tommy S. Tillman, Aina E. Cohen, Yan Xu, Pei Tang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/93fc7086c93940d39f5324fda014b220
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spelling oai:doaj.org-article:93fc7086c93940d39f5324fda014b2202021-12-02T15:34:37ZStructural basis of neurosteroid anesthetic action on GABAA receptors10.1038/s41467-018-06361-42041-1723https://doaj.org/article/93fc7086c93940d39f5324fda014b2202018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06361-4https://doaj.org/toc/2041-1723The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the development of new GABAAR modulators.Qiang ChenMarta M. WellsPalaniappa ArjunanTommy S. TillmanAina E. CohenYan XuPei TangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qiang Chen
Marta M. Wells
Palaniappa Arjunan
Tommy S. Tillman
Aina E. Cohen
Yan Xu
Pei Tang
Structural basis of neurosteroid anesthetic action on GABAA receptors
description The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the development of new GABAAR modulators.
format article
author Qiang Chen
Marta M. Wells
Palaniappa Arjunan
Tommy S. Tillman
Aina E. Cohen
Yan Xu
Pei Tang
author_facet Qiang Chen
Marta M. Wells
Palaniappa Arjunan
Tommy S. Tillman
Aina E. Cohen
Yan Xu
Pei Tang
author_sort Qiang Chen
title Structural basis of neurosteroid anesthetic action on GABAA receptors
title_short Structural basis of neurosteroid anesthetic action on GABAA receptors
title_full Structural basis of neurosteroid anesthetic action on GABAA receptors
title_fullStr Structural basis of neurosteroid anesthetic action on GABAA receptors
title_full_unstemmed Structural basis of neurosteroid anesthetic action on GABAA receptors
title_sort structural basis of neurosteroid anesthetic action on gabaa receptors
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/93fc7086c93940d39f5324fda014b220
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AT palaniappaarjunan structuralbasisofneurosteroidanestheticactionongabaareceptors
AT tommystillman structuralbasisofneurosteroidanestheticactionongabaareceptors
AT ainaecohen structuralbasisofneurosteroidanestheticactionongabaareceptors
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