Structural basis of neurosteroid anesthetic action on GABAA receptors
The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the d...
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Nature Portfolio
2018
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oai:doaj.org-article:93fc7086c93940d39f5324fda014b2202021-12-02T15:34:37ZStructural basis of neurosteroid anesthetic action on GABAA receptors10.1038/s41467-018-06361-42041-1723https://doaj.org/article/93fc7086c93940d39f5324fda014b2202018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06361-4https://doaj.org/toc/2041-1723The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the development of new GABAAR modulators.Qiang ChenMarta M. WellsPalaniappa ArjunanTommy S. TillmanAina E. CohenYan XuPei TangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
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Science Q Qiang Chen Marta M. Wells Palaniappa Arjunan Tommy S. Tillman Aina E. Cohen Yan Xu Pei Tang Structural basis of neurosteroid anesthetic action on GABAA receptors |
description |
The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the development of new GABAAR modulators. |
format |
article |
author |
Qiang Chen Marta M. Wells Palaniappa Arjunan Tommy S. Tillman Aina E. Cohen Yan Xu Pei Tang |
author_facet |
Qiang Chen Marta M. Wells Palaniappa Arjunan Tommy S. Tillman Aina E. Cohen Yan Xu Pei Tang |
author_sort |
Qiang Chen |
title |
Structural basis of neurosteroid anesthetic action on GABAA receptors |
title_short |
Structural basis of neurosteroid anesthetic action on GABAA receptors |
title_full |
Structural basis of neurosteroid anesthetic action on GABAA receptors |
title_fullStr |
Structural basis of neurosteroid anesthetic action on GABAA receptors |
title_full_unstemmed |
Structural basis of neurosteroid anesthetic action on GABAA receptors |
title_sort |
structural basis of neurosteroid anesthetic action on gabaa receptors |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/93fc7086c93940d39f5324fda014b220 |
work_keys_str_mv |
AT qiangchen structuralbasisofneurosteroidanestheticactionongabaareceptors AT martamwells structuralbasisofneurosteroidanestheticactionongabaareceptors AT palaniappaarjunan structuralbasisofneurosteroidanestheticactionongabaareceptors AT tommystillman structuralbasisofneurosteroidanestheticactionongabaareceptors AT ainaecohen structuralbasisofneurosteroidanestheticactionongabaareceptors AT yanxu structuralbasisofneurosteroidanestheticactionongabaareceptors AT peitang structuralbasisofneurosteroidanestheticactionongabaareceptors |
_version_ |
1718386793764618240 |