Structural basis of neurosteroid anesthetic action on GABAA receptors
The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the d...
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| Auteurs principaux: | , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2018
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| Accès en ligne: | https://doaj.org/article/93fc7086c93940d39f5324fda014b220 |
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