EphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells

Andre M Gobin, James J Moon, Jennifer L WestDepartment of Bioengineering, Rice University, Houston, TX, USAAbstract: Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intra...

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Autores principales:	Andre M Gobin, James J Moon, Jennifer L West
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/93ff3f04a33442e7b21b3e02a5762176
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spelling	oai:doaj.org-article:93ff3f04a33442e7b21b3e02a57621762021-12-02T04:46:21ZEphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells1176-91141178-2013https://doaj.org/article/93ff3f04a33442e7b21b3e02a57621762008-10-01T00:00:00Zhttp://www.dovepress.com/ephrina1-targeted-nanoshells-for-photothermal-ablation-of-prostate-can-a2434https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Andre M Gobin, James J Moon, Jennifer L WestDepartment of Bioengineering, Rice University, Houston, TX, USAAbstract: Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intravenously, these nanoshells have been shown to accumulate in tumors and subsequently mediate photothermal treatment, leading to tumor regression. In this work, we sought to improve their specificity by targeting them to prostate tumor cells. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA1, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.Keywords: nanoshell, near infrared, photothermal treatment, prostate cancer Andre M GobinJames J MoonJennifer L WestDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 3, Pp 351-358 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Andre M Gobin James J Moon Jennifer L West EphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells
description	Andre M Gobin, James J Moon, Jennifer L WestDepartment of Bioengineering, Rice University, Houston, TX, USAAbstract: Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intravenously, these nanoshells have been shown to accumulate in tumors and subsequently mediate photothermal treatment, leading to tumor regression. In this work, we sought to improve their specificity by targeting them to prostate tumor cells. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA1, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.Keywords: nanoshell, near infrared, photothermal treatment, prostate cancer
format	article
author	Andre M Gobin James J Moon Jennifer L West
author_facet	Andre M Gobin James J Moon Jennifer L West
author_sort	Andre M Gobin
title	EphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells
title_short	EphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells
title_full	EphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells
title_fullStr	EphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells
title_full_unstemmed	EphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells
title_sort	ephrina1-targeted nanoshells for photothermal ablation of prostate cancer cells
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/93ff3f04a33442e7b21b3e02a5762176
work_keys_str_mv	AT andremgobin ephrina1targetednanoshellsforphotothermalablationofprostatecancercells AT jamesjmoon ephrina1targetednanoshellsforphotothermalablationofprostatecancercells AT jenniferlwest ephrina1targetednanoshellsforphotothermalablationofprostatecancercells
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EphrinA1-targeted nanoshells for photothermal ablation of prostate cancer cells

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