The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.

<h4>Objective</h4>Insulin-like growth factor I (IGF-I) and dioxin-like polychlorobiphenyls (DL-PCBs) have been associated with the pathogenesis of several diseases like cancer, diabetes and growth disorders. Because it has been suggested that organohalogenated contaminants could influenc...

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Autores principales:	Octavio P Luzardo, Luis Alberto Henríquez-Hernández, Pilar F Valerón, Pedro C Lara, Maira Almeida-González, Antonio Losada, Manuel Zumbado, Lluis Serra-Majem, Eva Elisa Alvarez-León, Luis D Boada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9403929b7630466c9ffdd1b5af9f791f
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spelling	oai:doaj.org-article:9403929b7630466c9ffdd1b5af9f791f2021-11-18T07:17:02ZThe relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.1932-620310.1371/journal.pone.0038213https://doaj.org/article/9403929b7630466c9ffdd1b5af9f791f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22666488/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Insulin-like growth factor I (IGF-I) and dioxin-like polychlorobiphenyls (DL-PCBs) have been associated with the pathogenesis of several diseases like cancer, diabetes and growth disorders. Because it has been suggested that organohalogenated contaminants could influence IGF-I levels in adults, the potential relationship between DL-PCBs and IGF-I serum levels was studied in 456 healthy adults from a representative sample of the general population of the Canary Islands (Spain).<h4>Design</h4>Free circulating serum levels of IGF-I and IGFBP-3 were measured through an ELISA methodology, while the serum levels of the 12 DL-PCBs congeners (IUPAC numbers # 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, and 189) were measured by gas chromatography/mass spectrometry (GC-MS).<h4>Results</h4>DL-PCBs 156 and 167, Total DL-PCBs body burden (∑PCBs: sum over the 12 measured DL-PCBs), and Total toxic burden (in terms of toxic equivalence to dioxins: ∑TEQs) showed a trend of inverse association with IGF-I serum levels in the whole studied population. After adjusting for potential confounders, including gender, body mass index (BMI), age, and IGF-binding protein-3 (IGFBP-3), younger (18-45 years) women with lower BMI (<27 kg/m(2)) and detectable levels of DL-PCB-156 showed significantly lower IGF-I levels than those in the same age and BMI subgroup with non-detectable levels of DL-PCB-156 (p<0.001). Similarly, ∑PCBs and ∑TEQs showed a tendency to an inverse association with IGF-I levels in the same group of women (p=0.017 and p=0.019 respectively).<h4>Conclusions</h4>These findings suggest that DL-PCBs could be involved in the regulation of the IGF-system in a way possibly influenced by gender, age and BMI. Although these results should be interpreted with caution, such circumstances could contribute to explain the development of diseases associated to the IGF system.Octavio P LuzardoLuis Alberto Henríquez-HernándezPilar F ValerónPedro C LaraMaira Almeida-GonzálezAntonio LosadaManuel ZumbadoLluis Serra-MajemEva Elisa Alvarez-LeónLuis D BoadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e38213 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Octavio P Luzardo Luis Alberto Henríquez-Hernández Pilar F Valerón Pedro C Lara Maira Almeida-González Antonio Losada Manuel Zumbado Lluis Serra-Majem Eva Elisa Alvarez-León Luis D Boada The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.
description	<h4>Objective</h4>Insulin-like growth factor I (IGF-I) and dioxin-like polychlorobiphenyls (DL-PCBs) have been associated with the pathogenesis of several diseases like cancer, diabetes and growth disorders. Because it has been suggested that organohalogenated contaminants could influence IGF-I levels in adults, the potential relationship between DL-PCBs and IGF-I serum levels was studied in 456 healthy adults from a representative sample of the general population of the Canary Islands (Spain).<h4>Design</h4>Free circulating serum levels of IGF-I and IGFBP-3 were measured through an ELISA methodology, while the serum levels of the 12 DL-PCBs congeners (IUPAC numbers # 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, and 189) were measured by gas chromatography/mass spectrometry (GC-MS).<h4>Results</h4>DL-PCBs 156 and 167, Total DL-PCBs body burden (∑PCBs: sum over the 12 measured DL-PCBs), and Total toxic burden (in terms of toxic equivalence to dioxins: ∑TEQs) showed a trend of inverse association with IGF-I serum levels in the whole studied population. After adjusting for potential confounders, including gender, body mass index (BMI), age, and IGF-binding protein-3 (IGFBP-3), younger (18-45 years) women with lower BMI (<27 kg/m(2)) and detectable levels of DL-PCB-156 showed significantly lower IGF-I levels than those in the same age and BMI subgroup with non-detectable levels of DL-PCB-156 (p<0.001). Similarly, ∑PCBs and ∑TEQs showed a tendency to an inverse association with IGF-I levels in the same group of women (p=0.017 and p=0.019 respectively).<h4>Conclusions</h4>These findings suggest that DL-PCBs could be involved in the regulation of the IGF-system in a way possibly influenced by gender, age and BMI. Although these results should be interpreted with caution, such circumstances could contribute to explain the development of diseases associated to the IGF system.
format	article
author	Octavio P Luzardo Luis Alberto Henríquez-Hernández Pilar F Valerón Pedro C Lara Maira Almeida-González Antonio Losada Manuel Zumbado Lluis Serra-Majem Eva Elisa Alvarez-León Luis D Boada
author_facet	Octavio P Luzardo Luis Alberto Henríquez-Hernández Pilar F Valerón Pedro C Lara Maira Almeida-González Antonio Losada Manuel Zumbado Lluis Serra-Majem Eva Elisa Alvarez-León Luis D Boada
author_sort	Octavio P Luzardo
title	The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.
title_short	The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.
title_full	The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.
title_fullStr	The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.
title_full_unstemmed	The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.
title_sort	relationship between dioxin-like polychlorobiphenyls and igf-i serum levels in healthy adults: evidence from a cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9403929b7630466c9ffdd1b5af9f791f
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The relationship between dioxin-like polychlorobiphenyls and IGF-I serum levels in healthy adults: evidence from a cross-sectional study.

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