Complex events initiated by individual spikes in the human cerebral cortex.

Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and reveal complex events triggered by individual...

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Autores principales:	Gábor Molnár, Szabolcs Oláh, Gergely Komlósi, Miklós Füle, János Szabadics, Csaba Varga, Pál Barzó, Gábor Tamás
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9403c824590d4638bd79e9bc0247d072
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spelling	oai:doaj.org-article:9403c824590d4638bd79e9bc0247d0722021-11-25T05:33:57ZComplex events initiated by individual spikes in the human cerebral cortex.1544-91731545-788510.1371/journal.pbio.0060222https://doaj.org/article/9403c824590d4638bd79e9bc0247d0722008-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18767905/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and reveal complex events triggered by individual action potentials in the human neocortical network. Brain slices were prepared from nonpathological samples of cortex that had to be removed for the surgical treatment of brain areas beneath association cortices of 58 patients aged 18 to 73 y. Simultaneous triple and quadruple whole-cell patch clamp recordings were performed testing mono- and polysynaptic potentials in target neurons following a single action potential fired by layer 2/3 pyramidal cells, and the temporal structure of events and underlying mechanisms were analyzed. In addition to monosynaptic postsynaptic potentials, individual action potentials in presynaptic pyramidal cells initiated long-lasting (37 +/- 17 ms) sequences of events in the network lasting an order of magnitude longer than detected previously in other species. These event series were composed of specifically alternating glutamatergic and GABAergic postsynaptic potentials and required selective spike-to-spike coupling from pyramidal cells to GABAergic interneurons producing concomitant inhibitory as well as excitatory feed-forward action of GABA. Single action potentials of human neurons are sufficient to recruit Hebbian-like neuronal assemblies that are proposed to participate in cognitive processes.Gábor MolnárSzabolcs OláhGergely KomlósiMiklós FüleJános SzabadicsCsaba VargaCsaba VargaPál BarzóGábor TamásPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 9, p e222 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Gábor Molnár Szabolcs Oláh Gergely Komlósi Miklós Füle János Szabadics Csaba Varga Csaba Varga Pál Barzó Gábor Tamás Complex events initiated by individual spikes in the human cerebral cortex.
description	Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and reveal complex events triggered by individual action potentials in the human neocortical network. Brain slices were prepared from nonpathological samples of cortex that had to be removed for the surgical treatment of brain areas beneath association cortices of 58 patients aged 18 to 73 y. Simultaneous triple and quadruple whole-cell patch clamp recordings were performed testing mono- and polysynaptic potentials in target neurons following a single action potential fired by layer 2/3 pyramidal cells, and the temporal structure of events and underlying mechanisms were analyzed. In addition to monosynaptic postsynaptic potentials, individual action potentials in presynaptic pyramidal cells initiated long-lasting (37 +/- 17 ms) sequences of events in the network lasting an order of magnitude longer than detected previously in other species. These event series were composed of specifically alternating glutamatergic and GABAergic postsynaptic potentials and required selective spike-to-spike coupling from pyramidal cells to GABAergic interneurons producing concomitant inhibitory as well as excitatory feed-forward action of GABA. Single action potentials of human neurons are sufficient to recruit Hebbian-like neuronal assemblies that are proposed to participate in cognitive processes.
format	article
author	Gábor Molnár Szabolcs Oláh Gergely Komlósi Miklós Füle János Szabadics Csaba Varga Csaba Varga Pál Barzó Gábor Tamás
author_facet	Gábor Molnár Szabolcs Oláh Gergely Komlósi Miklós Füle János Szabadics Csaba Varga Csaba Varga Pál Barzó Gábor Tamás
author_sort	Gábor Molnár
title	Complex events initiated by individual spikes in the human cerebral cortex.
title_short	Complex events initiated by individual spikes in the human cerebral cortex.
title_full	Complex events initiated by individual spikes in the human cerebral cortex.
title_fullStr	Complex events initiated by individual spikes in the human cerebral cortex.
title_full_unstemmed	Complex events initiated by individual spikes in the human cerebral cortex.
title_sort	complex events initiated by individual spikes in the human cerebral cortex.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/9403c824590d4638bd79e9bc0247d072
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Complex events initiated by individual spikes in the human cerebral cortex.

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