A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors

It is unclear what role cholesterol-enriched domains of the plasma membrane play in mediating the development of neuronal circuits. Here, the authors show that such domains localize ephrin-A-induced cAMP signals, causing the pruning of retinal ganglion cell axons.

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Autores principales:	Stefania Averaimo, Ahlem Assali, Oriol Ros, Sandrine Couvet, Yvrick Zagar, Ioana Genescu, Alexandra Rebsam, Xavier Nicol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94050756e0ed422e8dfa1ae1650db453
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spelling	oai:doaj.org-article:94050756e0ed422e8dfa1ae1650db4532021-12-02T16:49:42ZA plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors10.1038/ncomms128962041-1723https://doaj.org/article/94050756e0ed422e8dfa1ae1650db4532016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12896https://doaj.org/toc/2041-1723It is unclear what role cholesterol-enriched domains of the plasma membrane play in mediating the development of neuronal circuits. Here, the authors show that such domains localize ephrin-A-induced cAMP signals, causing the pruning of retinal ganglion cell axons.Stefania AveraimoAhlem AssaliOriol RosSandrine CouvetYvrick ZagarIoana GenescuAlexandra RebsamXavier NicolNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefania Averaimo Ahlem Assali Oriol Ros Sandrine Couvet Yvrick Zagar Ioana Genescu Alexandra Rebsam Xavier Nicol A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors
description	It is unclear what role cholesterol-enriched domains of the plasma membrane play in mediating the development of neuronal circuits. Here, the authors show that such domains localize ephrin-A-induced cAMP signals, causing the pruning of retinal ganglion cell axons.
format	article
author	Stefania Averaimo Ahlem Assali Oriol Ros Sandrine Couvet Yvrick Zagar Ioana Genescu Alexandra Rebsam Xavier Nicol
author_facet	Stefania Averaimo Ahlem Assali Oriol Ros Sandrine Couvet Yvrick Zagar Ioana Genescu Alexandra Rebsam Xavier Nicol
author_sort	Stefania Averaimo
title	A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors
title_short	A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors
title_full	A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors
title_fullStr	A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors
title_full_unstemmed	A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors
title_sort	plasma membrane microdomain compartmentalizes ephrin-generated camp signals to prune developing retinal axon arbors
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/94050756e0ed422e8dfa1ae1650db453
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A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors

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