An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

Immunological adjuvants are a crucial component of cancer vaccines. Here the authors design a light-activable immunological adjuvant, based on hypoxia-responsive amphiphilic dendrimer nanoparticles loaded with a photodynamic agent, promoting anti-tumor immune responses in preclinical cancer models.

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Autores principales: Yongchao Wang, Ningqiang Gong, Chi Ma, Yuxuan Zhang, Hong Tan, Guangchao Qing, Jimei Zhang, Yufei Wang, Jinjin Wang, Shizhu Chen, Xianlei Li, Qiankun Ni, Yuan Yuan, Yaling Gan, Junge Chen, Fangzhou Li, Jinchao Zhang, Caiwen Ou, Yongxiang Zhao, Xiaoxuan Liu, Xing-Jie Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/9406f8b05e734a97845b344a34803f0b
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spelling oai:doaj.org-article:9406f8b05e734a97845b344a34803f0b2021-12-02T15:10:47ZAn amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination10.1038/s41467-021-25197-z2041-1723https://doaj.org/article/9406f8b05e734a97845b344a34803f0b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25197-zhttps://doaj.org/toc/2041-1723Immunological adjuvants are a crucial component of cancer vaccines. Here the authors design a light-activable immunological adjuvant, based on hypoxia-responsive amphiphilic dendrimer nanoparticles loaded with a photodynamic agent, promoting anti-tumor immune responses in preclinical cancer models.Yongchao WangNingqiang GongChi MaYuxuan ZhangHong TanGuangchao QingJimei ZhangYufei WangJinjin WangShizhu ChenXianlei LiQiankun NiYuan YuanYaling GanJunge ChenFangzhou LiJinchao ZhangCaiwen OuYongxiang ZhaoXiaoxuan LiuXing-Jie LiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yongchao Wang
Ningqiang Gong
Chi Ma
Yuxuan Zhang
Hong Tan
Guangchao Qing
Jimei Zhang
Yufei Wang
Jinjin Wang
Shizhu Chen
Xianlei Li
Qiankun Ni
Yuan Yuan
Yaling Gan
Junge Chen
Fangzhou Li
Jinchao Zhang
Caiwen Ou
Yongxiang Zhao
Xiaoxuan Liu
Xing-Jie Liang
An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
description Immunological adjuvants are a crucial component of cancer vaccines. Here the authors design a light-activable immunological adjuvant, based on hypoxia-responsive amphiphilic dendrimer nanoparticles loaded with a photodynamic agent, promoting anti-tumor immune responses in preclinical cancer models.
format article
author Yongchao Wang
Ningqiang Gong
Chi Ma
Yuxuan Zhang
Hong Tan
Guangchao Qing
Jimei Zhang
Yufei Wang
Jinjin Wang
Shizhu Chen
Xianlei Li
Qiankun Ni
Yuan Yuan
Yaling Gan
Junge Chen
Fangzhou Li
Jinchao Zhang
Caiwen Ou
Yongxiang Zhao
Xiaoxuan Liu
Xing-Jie Liang
author_facet Yongchao Wang
Ningqiang Gong
Chi Ma
Yuxuan Zhang
Hong Tan
Guangchao Qing
Jimei Zhang
Yufei Wang
Jinjin Wang
Shizhu Chen
Xianlei Li
Qiankun Ni
Yuan Yuan
Yaling Gan
Junge Chen
Fangzhou Li
Jinchao Zhang
Caiwen Ou
Yongxiang Zhao
Xiaoxuan Liu
Xing-Jie Liang
author_sort Yongchao Wang
title An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
title_short An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
title_full An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
title_fullStr An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
title_full_unstemmed An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
title_sort amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/9406f8b05e734a97845b344a34803f0b
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