An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair

Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiacheng Guo, Zhenzhen Yang, Yongzheng Lu, Chunyan Du, Chang Cao, Bo Wang, Xiaoting Yue, Zenglei Zhang, Yanyan Xu, Zhen Qin, Tingting Huang, Wei Wang, Wei Jiang, Jinying Zhang, Junnan Tang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Acute myocardial infarction Immobilized enzyme Reactive oxygen species Nanomedicine Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9407740217564e219c624de81ce3833b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9407740217564e219c624de81ce3833b
record_format	dspace
spelling	oai:doaj.org-article:9407740217564e219c624de81ce3833b2021-11-26T04:36:48ZAn antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair2452-199X10.1016/j.bioactmat.2021.08.019https://doaj.org/article/9407740217564e219c624de81ce3833b2022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003959https://doaj.org/toc/2452-199XAcute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-link with Zr-based metal-organic framework (ZrMOF) (SOD-ZrMOF) for mitigate ROS-caused injury. In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility. By efficiently scavenging ROS and suppressing oxidative stress, SOD-ZrMOF can protect the function of mitochondria, reduce cell death and alleviate inflammation. More excitingly, long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area, protect cardiac function, promote angiogenesis and inhibit pathological myocardial remodeling. Therefore, SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI.Jiacheng GuoZhenzhen YangYongzheng LuChunyan DuChang CaoBo WangXiaoting YueZenglei ZhangYanyan XuZhen QinTingting HuangWei WangWei JiangJinying ZhangJunnan TangKeAi Communications Co., Ltd.articleAcute myocardial infarctionImmobilized enzymeReactive oxygen speciesNanomedicineMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 56-67 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute myocardial infarction Immobilized enzyme Reactive oxygen species Nanomedicine Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Acute myocardial infarction Immobilized enzyme Reactive oxygen species Nanomedicine Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
description	Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-link with Zr-based metal-organic framework (ZrMOF) (SOD-ZrMOF) for mitigate ROS-caused injury. In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility. By efficiently scavenging ROS and suppressing oxidative stress, SOD-ZrMOF can protect the function of mitochondria, reduce cell death and alleviate inflammation. More excitingly, long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area, protect cardiac function, promote angiogenesis and inhibit pathological myocardial remodeling. Therefore, SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI.
format	article
author	Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang
author_facet	Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang
author_sort	Jiacheng Guo
title	An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
title_short	An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
title_full	An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
title_fullStr	An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
title_full_unstemmed	An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
title_sort	antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/9407740217564e219c624de81ce3833b
work_keys_str_mv	AT jiachengguo anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT zhenzhenyang anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT yongzhenglu anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT chunyandu anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT changcao anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT bowang anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT xiaotingyue anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT zengleizhang anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT yanyanxu anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT zhenqin anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT tingtinghuang anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT weiwang anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT weijiang anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT jinyingzhang anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT junnantang anantioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT jiachengguo antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT zhenzhenyang antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT yongzhenglu antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT chunyandu antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT changcao antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT bowang antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT xiaotingyue antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT zengleizhang antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT yanyanxu antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT zhenqin antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT tingtinghuang antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT weiwang antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT weijiang antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT jinyingzhang antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair AT junnantang antioxidantsystemthroughconjugatingsuperoxidedismutaseontometalorganicframeworkforcardiacrepair
_version_	1718409855199346688

An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair

Ejemplares similares