Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease

We present a case of extramammary Paget’s disease with bilateral inguinal lymph node metastasis treated by monthly docetaxel chemotherapy. He has also well-controlled psoriasis vulgaris for 20 years. One day after completing monthly chemotherapy, cellulitis by Group G Streptococcus occurred on both...

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Autores principales:	Takehisa Nakanishi, Makoto Kondo, Yasuo Nakai, Koji Habe, Keiichi Yamanaka
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	tumor necrosis factor-alpha psoriasis vulgaris extramammary paget’s disease group g streptococcal infection cytokine storm Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/940a7ce70a774a0cb261421c8ad68db4
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spelling	oai:doaj.org-article:940a7ce70a774a0cb261421c8ad68db42021-12-02T12:40:23ZReduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease1662-657510.1159/000519589https://doaj.org/article/940a7ce70a774a0cb261421c8ad68db42021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/519589https://doaj.org/toc/1662-6575We present a case of extramammary Paget’s disease with bilateral inguinal lymph node metastasis treated by monthly docetaxel chemotherapy. He has also well-controlled psoriasis vulgaris for 20 years. One day after completing monthly chemotherapy, cellulitis by Group G Streptococcus occurred on both legs, resulting in septic shock and disseminated intravascular coagulation. During the infection, the tumor nodule volume and the exudate from the tumor decreased, and tumor markers carcinoembryonic antigen and cancer antigen 19-9 showed low values. Simultaneously, the psoriatic eruption reoccurred. We proposed that cytokine storm including tumor necrosis factor-alpha (TNF-α) during sepsis might have suppressed tumor lesions, and also TNF-α-dependent psoriatic rash appeared temporarily on his body.Takehisa NakanishiMakoto KondoYasuo NakaiKoji HabeKeiichi YamanakaKarger Publishersarticletumor necrosis factor-alphapsoriasis vulgarisextramammary paget’s diseasegroup g streptococcal infectioncytokine stormNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1591-1595 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor necrosis factor-alpha psoriasis vulgaris extramammary paget’s disease group g streptococcal infection cytokine storm Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	tumor necrosis factor-alpha psoriasis vulgaris extramammary paget’s disease group g streptococcal infection cytokine storm Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Takehisa Nakanishi Makoto Kondo Yasuo Nakai Koji Habe Keiichi Yamanaka Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease
description	We present a case of extramammary Paget’s disease with bilateral inguinal lymph node metastasis treated by monthly docetaxel chemotherapy. He has also well-controlled psoriasis vulgaris for 20 years. One day after completing monthly chemotherapy, cellulitis by Group G Streptococcus occurred on both legs, resulting in septic shock and disseminated intravascular coagulation. During the infection, the tumor nodule volume and the exudate from the tumor decreased, and tumor markers carcinoembryonic antigen and cancer antigen 19-9 showed low values. Simultaneously, the psoriatic eruption reoccurred. We proposed that cytokine storm including tumor necrosis factor-alpha (TNF-α) during sepsis might have suppressed tumor lesions, and also TNF-α-dependent psoriatic rash appeared temporarily on his body.
format	article
author	Takehisa Nakanishi Makoto Kondo Yasuo Nakai Koji Habe Keiichi Yamanaka
author_facet	Takehisa Nakanishi Makoto Kondo Yasuo Nakai Koji Habe Keiichi Yamanaka
author_sort	Takehisa Nakanishi
title	Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease
title_short	Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease
title_full	Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease
title_fullStr	Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease
title_full_unstemmed	Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease
title_sort	reduction in tumor lesions and exacerbation of psoriatic rash after septic shock in a patient with extramammary paget’s disease
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/940a7ce70a774a0cb261421c8ad68db4
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Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease

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