A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation
Summary: It is well established that the early malignant tumor invades surrounding extracellular matrix (ECM) in a manner that depends upon material properties of constituent cells, surrounding ECM, and their interactions. Recent studies have established the capacity of the invading tumor spheroids...
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Elsevier
2021
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oai:doaj.org-article:940b9644a5384a00ab965aa9bfe5e0562021-11-20T05:08:53ZA novel jamming phase diagram links tumor invasion to non-equilibrium phase separation2589-004210.1016/j.isci.2021.103252https://doaj.org/article/940b9644a5384a00ab965aa9bfe5e0562021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012219https://doaj.org/toc/2589-0042Summary: It is well established that the early malignant tumor invades surrounding extracellular matrix (ECM) in a manner that depends upon material properties of constituent cells, surrounding ECM, and their interactions. Recent studies have established the capacity of the invading tumor spheroids to evolve into coexistent solid-like, fluid-like, and gas-like phases. Using breast cancer cell lines invading into engineered ECM, here we show that the spheroid interior develops spatial and temporal heterogeneities in material phase which, depending upon cell type and matrix density, ultimately result in a variety of phase separation patterns at the invasive front. Using a computational approach, we further show that these patterns are captured by a novel jamming phase diagram. We suggest that non-equilibrium phase separation based upon jamming and unjamming transitions may provide a unifying physical picture to describe cellular migratory dynamics within, and invasion from, a tumor.Wenying KangJacopo FerruzziCatalina-Paula SpatareluYu Long HanYasha SharmaStephan A. KoehlerJennifer A. MitchelAdil KhanJames P. ButlerDarren RoblyerMuhammad H. ZamanJin-Ah ParkMing GuoZi ChenAdrian F. PegoraroJeffrey J. FredbergElsevierarticleBiophysicsCancerMechanobiologyScienceQENiScience, Vol 24, Iss 11, Pp 103252- (2021) |
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DOAJ |
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DOAJ |
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EN |
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Biophysics Cancer Mechanobiology Science Q |
| spellingShingle |
Biophysics Cancer Mechanobiology Science Q Wenying Kang Jacopo Ferruzzi Catalina-Paula Spatarelu Yu Long Han Yasha Sharma Stephan A. Koehler Jennifer A. Mitchel Adil Khan James P. Butler Darren Roblyer Muhammad H. Zaman Jin-Ah Park Ming Guo Zi Chen Adrian F. Pegoraro Jeffrey J. Fredberg A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation |
| description |
Summary: It is well established that the early malignant tumor invades surrounding extracellular matrix (ECM) in a manner that depends upon material properties of constituent cells, surrounding ECM, and their interactions. Recent studies have established the capacity of the invading tumor spheroids to evolve into coexistent solid-like, fluid-like, and gas-like phases. Using breast cancer cell lines invading into engineered ECM, here we show that the spheroid interior develops spatial and temporal heterogeneities in material phase which, depending upon cell type and matrix density, ultimately result in a variety of phase separation patterns at the invasive front. Using a computational approach, we further show that these patterns are captured by a novel jamming phase diagram. We suggest that non-equilibrium phase separation based upon jamming and unjamming transitions may provide a unifying physical picture to describe cellular migratory dynamics within, and invasion from, a tumor. |
| format |
article |
| author |
Wenying Kang Jacopo Ferruzzi Catalina-Paula Spatarelu Yu Long Han Yasha Sharma Stephan A. Koehler Jennifer A. Mitchel Adil Khan James P. Butler Darren Roblyer Muhammad H. Zaman Jin-Ah Park Ming Guo Zi Chen Adrian F. Pegoraro Jeffrey J. Fredberg |
| author_facet |
Wenying Kang Jacopo Ferruzzi Catalina-Paula Spatarelu Yu Long Han Yasha Sharma Stephan A. Koehler Jennifer A. Mitchel Adil Khan James P. Butler Darren Roblyer Muhammad H. Zaman Jin-Ah Park Ming Guo Zi Chen Adrian F. Pegoraro Jeffrey J. Fredberg |
| author_sort |
Wenying Kang |
| title |
A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation |
| title_short |
A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation |
| title_full |
A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation |
| title_fullStr |
A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation |
| title_full_unstemmed |
A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation |
| title_sort |
novel jamming phase diagram links tumor invasion to non-equilibrium phase separation |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/940b9644a5384a00ab965aa9bfe5e056 |
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