Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.

<h4>Introduction</h4>The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CR...

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Autores principales:	Gemma Ibáñez-Sanz, Núria Milà, Carmen Vidal, Judith Rocamora, Víctor Moreno, Rebeca Sanz-Pamplona, Montse Garcia, MSIC-SC research group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94116d88d23c4cf596ff5d2bf6387550
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spelling	oai:doaj.org-article:94116d88d23c4cf596ff5d2bf63875502021-12-02T20:15:46ZPositive impact of a faecal-based screening programme on colorectal cancer mortality risk.1932-620310.1371/journal.pone.0253369https://doaj.org/article/94116d88d23c4cf596ff5d2bf63875502021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253369https://doaj.org/toc/1932-6203<h4>Introduction</h4>The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-detected cancers, interval cancers, and cancers among the non-uptake group).<h4>Material and methods</h4>Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. A screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); an interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (≤24 months); a non-uptake cancer was a cancer in subjects who declined screening.<h4>Results</h4>A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs.<h4>Conclusion</h4>CRC screening with the FIT was associated with a significant reduction in CRC mortality.Gemma Ibáñez-SanzNúria MilàCarmen VidalJudith RocamoraVíctor MorenoRebeca Sanz-PamplonaMontse GarciaMSIC-SC research groupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253369 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gemma Ibáñez-Sanz Núria Milà Carmen Vidal Judith Rocamora Víctor Moreno Rebeca Sanz-Pamplona Montse Garcia MSIC-SC research group Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.
description	<h4>Introduction</h4>The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-detected cancers, interval cancers, and cancers among the non-uptake group).<h4>Material and methods</h4>Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. A screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); an interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (≤24 months); a non-uptake cancer was a cancer in subjects who declined screening.<h4>Results</h4>A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs.<h4>Conclusion</h4>CRC screening with the FIT was associated with a significant reduction in CRC mortality.
format	article
author	Gemma Ibáñez-Sanz Núria Milà Carmen Vidal Judith Rocamora Víctor Moreno Rebeca Sanz-Pamplona Montse Garcia MSIC-SC research group
author_facet	Gemma Ibáñez-Sanz Núria Milà Carmen Vidal Judith Rocamora Víctor Moreno Rebeca Sanz-Pamplona Montse Garcia MSIC-SC research group
author_sort	Gemma Ibáñez-Sanz
title	Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.
title_short	Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.
title_full	Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.
title_fullStr	Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.
title_full_unstemmed	Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.
title_sort	positive impact of a faecal-based screening programme on colorectal cancer mortality risk.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/94116d88d23c4cf596ff5d2bf6387550
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Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.

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