The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
Abstract Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk. To better define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomic assay to analyze moderate-to-severe AD (n =...
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Nature Portfolio
2017
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oai:doaj.org-article:94124255e4b143c7b0ea37defc9090d42021-12-02T15:05:31ZThe atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins10.1038/s41598-017-09207-z2045-2322https://doaj.org/article/94124255e4b143c7b0ea37defc9090d42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09207-zhttps://doaj.org/toc/2045-2322Abstract Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk. To better define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomic assay to analyze moderate-to-severe AD (n = 59) compared to psoriasis (n = 22) and healthy controls (n = 18). Compared to controls, 10 proteins were increased in serum of both diseases, including Th1 (IFN-γ, CXCL9, TNF-β) and Th17 (CCL20) markers. 48 proteins each were uniquely upregulated in AD and psoriasis. Consistent with skin expression, AD serum showed up-regulation of Th2 (IL-13, CCL17, eotaxin-1/CCL11, CCL13, CCL4, IL-10), Th1 (CXCL10, CXCL11) and Th1/Th17/Th22 (IL-12/IL-23p40) responses. Surprisingly, some markers of atherosclerosis (fractalkine/CX3CL1, CCL8, M-CSF, HGF), T-cell development/activation (CD40L, IL-7, CCL25, IL-2RB, IL-15RA, CD6) and angiogenesis (VEGF-A) were significantly increased only in AD. Multiple inflammatory pathways showed stronger enrichment in AD than psoriasis. Several atherosclerosis mediators in serum (e.g. E-selectin, PI3/elafin, CCL7, IL-16) correlated with SCORAD, but not BMI. Also, AD inflammatory mediators (e.g. MMP12, IL-12/IL-23p40, CXCL9, CCL22, PI3/Elafin) correlated between blood and lesional as well as non-lesional skin. Overall, the AD blood signature was largely different compared to psoriasis, with dysregulation of inflammatory and cardiovascular risk markers, strongly supporting its systemic nature beyond atopic/allergic association.Patrick M. BrunnerMayte Suárez-FariñasHelen HeKunal MalikHuei-Chi WenJuana GonzalezTom Chih-Chieh ChanYeriel EstradaXiuzhong ZhengSaakshi KhattriAnnunziata DattolaJames G. KruegerEmma Guttman-YasskyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
| institution |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Patrick M. Brunner Mayte Suárez-Fariñas Helen He Kunal Malik Huei-Chi Wen Juana Gonzalez Tom Chih-Chieh Chan Yeriel Estrada Xiuzhong Zheng Saakshi Khattri Annunziata Dattola James G. Krueger Emma Guttman-Yassky The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins |
| description |
Abstract Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk. To better define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomic assay to analyze moderate-to-severe AD (n = 59) compared to psoriasis (n = 22) and healthy controls (n = 18). Compared to controls, 10 proteins were increased in serum of both diseases, including Th1 (IFN-γ, CXCL9, TNF-β) and Th17 (CCL20) markers. 48 proteins each were uniquely upregulated in AD and psoriasis. Consistent with skin expression, AD serum showed up-regulation of Th2 (IL-13, CCL17, eotaxin-1/CCL11, CCL13, CCL4, IL-10), Th1 (CXCL10, CXCL11) and Th1/Th17/Th22 (IL-12/IL-23p40) responses. Surprisingly, some markers of atherosclerosis (fractalkine/CX3CL1, CCL8, M-CSF, HGF), T-cell development/activation (CD40L, IL-7, CCL25, IL-2RB, IL-15RA, CD6) and angiogenesis (VEGF-A) were significantly increased only in AD. Multiple inflammatory pathways showed stronger enrichment in AD than psoriasis. Several atherosclerosis mediators in serum (e.g. E-selectin, PI3/elafin, CCL7, IL-16) correlated with SCORAD, but not BMI. Also, AD inflammatory mediators (e.g. MMP12, IL-12/IL-23p40, CXCL9, CCL22, PI3/Elafin) correlated between blood and lesional as well as non-lesional skin. Overall, the AD blood signature was largely different compared to psoriasis, with dysregulation of inflammatory and cardiovascular risk markers, strongly supporting its systemic nature beyond atopic/allergic association. |
| format |
article |
| author |
Patrick M. Brunner Mayte Suárez-Fariñas Helen He Kunal Malik Huei-Chi Wen Juana Gonzalez Tom Chih-Chieh Chan Yeriel Estrada Xiuzhong Zheng Saakshi Khattri Annunziata Dattola James G. Krueger Emma Guttman-Yassky |
| author_facet |
Patrick M. Brunner Mayte Suárez-Fariñas Helen He Kunal Malik Huei-Chi Wen Juana Gonzalez Tom Chih-Chieh Chan Yeriel Estrada Xiuzhong Zheng Saakshi Khattri Annunziata Dattola James G. Krueger Emma Guttman-Yassky |
| author_sort |
Patrick M. Brunner |
| title |
The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins |
| title_short |
The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins |
| title_full |
The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins |
| title_fullStr |
The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins |
| title_full_unstemmed |
The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins |
| title_sort |
atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/94124255e4b143c7b0ea37defc9090d4 |
| work_keys_str_mv |
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