The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins

Abstract Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk. To better define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomic assay to analyze moderate-to-severe AD (n =...

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Autores principales: Patrick M. Brunner, Mayte Suárez-Fariñas, Helen He, Kunal Malik, Huei-Chi Wen, Juana Gonzalez, Tom Chih-Chieh Chan, Yeriel Estrada, Xiuzhong Zheng, Saakshi Khattri, Annunziata Dattola, James G. Krueger, Emma Guttman-Yassky
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Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:94124255e4b143c7b0ea37defc9090d42021-12-02T15:05:31ZThe atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins10.1038/s41598-017-09207-z2045-2322https://doaj.org/article/94124255e4b143c7b0ea37defc9090d42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09207-zhttps://doaj.org/toc/2045-2322Abstract Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk. To better define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomic assay to analyze moderate-to-severe AD (n = 59) compared to psoriasis (n = 22) and healthy controls (n = 18). Compared to controls, 10 proteins were increased in serum of both diseases, including Th1 (IFN-γ, CXCL9, TNF-β) and Th17 (CCL20) markers. 48 proteins each were uniquely upregulated in AD and psoriasis. Consistent with skin expression, AD serum showed up-regulation of Th2 (IL-13, CCL17, eotaxin-1/CCL11, CCL13, CCL4, IL-10), Th1 (CXCL10, CXCL11) and Th1/Th17/Th22 (IL-12/IL-23p40) responses. Surprisingly, some markers of atherosclerosis (fractalkine/CX3CL1, CCL8, M-CSF, HGF), T-cell development/activation (CD40L, IL-7, CCL25, IL-2RB, IL-15RA, CD6) and angiogenesis (VEGF-A) were significantly increased only in AD. Multiple inflammatory pathways showed stronger enrichment in AD than psoriasis. Several atherosclerosis mediators in serum (e.g. E-selectin, PI3/elafin, CCL7, IL-16) correlated with SCORAD, but not BMI. Also, AD inflammatory mediators (e.g. MMP12, IL-12/IL-23p40, CXCL9, CCL22, PI3/Elafin) correlated between blood and lesional as well as non-lesional skin. Overall, the AD blood signature was largely different compared to psoriasis, with dysregulation of inflammatory and cardiovascular risk markers, strongly supporting its systemic nature beyond atopic/allergic association.Patrick M. BrunnerMayte Suárez-FariñasHelen HeKunal MalikHuei-Chi WenJuana GonzalezTom Chih-Chieh ChanYeriel EstradaXiuzhong ZhengSaakshi KhattriAnnunziata DattolaJames G. KruegerEmma Guttman-YasskyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Patrick M. Brunner
Mayte Suárez-Fariñas
Helen He
Kunal Malik
Huei-Chi Wen
Juana Gonzalez
Tom Chih-Chieh Chan
Yeriel Estrada
Xiuzhong Zheng
Saakshi Khattri
Annunziata Dattola
James G. Krueger
Emma Guttman-Yassky
The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
description Abstract Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk. To better define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomic assay to analyze moderate-to-severe AD (n = 59) compared to psoriasis (n = 22) and healthy controls (n = 18). Compared to controls, 10 proteins were increased in serum of both diseases, including Th1 (IFN-γ, CXCL9, TNF-β) and Th17 (CCL20) markers. 48 proteins each were uniquely upregulated in AD and psoriasis. Consistent with skin expression, AD serum showed up-regulation of Th2 (IL-13, CCL17, eotaxin-1/CCL11, CCL13, CCL4, IL-10), Th1 (CXCL10, CXCL11) and Th1/Th17/Th22 (IL-12/IL-23p40) responses. Surprisingly, some markers of atherosclerosis (fractalkine/CX3CL1, CCL8, M-CSF, HGF), T-cell development/activation (CD40L, IL-7, CCL25, IL-2RB, IL-15RA, CD6) and angiogenesis (VEGF-A) were significantly increased only in AD. Multiple inflammatory pathways showed stronger enrichment in AD than psoriasis. Several atherosclerosis mediators in serum (e.g. E-selectin, PI3/elafin, CCL7, IL-16) correlated with SCORAD, but not BMI. Also, AD inflammatory mediators (e.g. MMP12, IL-12/IL-23p40, CXCL9, CCL22, PI3/Elafin) correlated between blood and lesional as well as non-lesional skin. Overall, the AD blood signature was largely different compared to psoriasis, with dysregulation of inflammatory and cardiovascular risk markers, strongly supporting its systemic nature beyond atopic/allergic association.
format article
author Patrick M. Brunner
Mayte Suárez-Fariñas
Helen He
Kunal Malik
Huei-Chi Wen
Juana Gonzalez
Tom Chih-Chieh Chan
Yeriel Estrada
Xiuzhong Zheng
Saakshi Khattri
Annunziata Dattola
James G. Krueger
Emma Guttman-Yassky
author_facet Patrick M. Brunner
Mayte Suárez-Fariñas
Helen He
Kunal Malik
Huei-Chi Wen
Juana Gonzalez
Tom Chih-Chieh Chan
Yeriel Estrada
Xiuzhong Zheng
Saakshi Khattri
Annunziata Dattola
James G. Krueger
Emma Guttman-Yassky
author_sort Patrick M. Brunner
title The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
title_short The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
title_full The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
title_fullStr The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
title_full_unstemmed The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
title_sort atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/94124255e4b143c7b0ea37defc9090d4
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