Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity

The anti-tumour immune response greatly depends on the number of tumour neoantigens. Here the authors show in mouse models that a therapeutic strategy aimed at increasing the number of neoantigens via downregulating TAP, an antigen processing associated protein, enhances anti-tumour immunity and the...

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Autores principales:	Greta Garrido, Brett Schrand, Ailem Rabasa, Agata Levay, Francesca D’Eramo, Alexey Berezhnoy, Shrey Modi, Tal Gefen, Koen Marijt, Elien Doorduijn, Vikas Dudeja, Thorbald van Hall, Eli Gilboa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9412b6e3bd1140079d62c6a2a9c464d0
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spelling	oai:doaj.org-article:9412b6e3bd1140079d62c6a2a9c464d02021-12-02T16:57:20ZTumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity10.1038/s41467-019-11728-22041-1723https://doaj.org/article/9412b6e3bd1140079d62c6a2a9c464d02019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11728-2https://doaj.org/toc/2041-1723The anti-tumour immune response greatly depends on the number of tumour neoantigens. Here the authors show in mouse models that a therapeutic strategy aimed at increasing the number of neoantigens via downregulating TAP, an antigen processing associated protein, enhances anti-tumour immunity and the efficacy of immunotherapy.Greta GarridoBrett SchrandAilem RabasaAgata LevayFrancesca D’EramoAlexey BerezhnoyShrey ModiTal GefenKoen MarijtElien DoorduijnVikas DudejaThorbald van HallEli GilboaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Greta Garrido Brett Schrand Ailem Rabasa Agata Levay Francesca D’Eramo Alexey Berezhnoy Shrey Modi Tal Gefen Koen Marijt Elien Doorduijn Vikas Dudeja Thorbald van Hall Eli Gilboa Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
description	The anti-tumour immune response greatly depends on the number of tumour neoantigens. Here the authors show in mouse models that a therapeutic strategy aimed at increasing the number of neoantigens via downregulating TAP, an antigen processing associated protein, enhances anti-tumour immunity and the efficacy of immunotherapy.
format	article
author	Greta Garrido Brett Schrand Ailem Rabasa Agata Levay Francesca D’Eramo Alexey Berezhnoy Shrey Modi Tal Gefen Koen Marijt Elien Doorduijn Vikas Dudeja Thorbald van Hall Eli Gilboa
author_facet	Greta Garrido Brett Schrand Ailem Rabasa Agata Levay Francesca D’Eramo Alexey Berezhnoy Shrey Modi Tal Gefen Koen Marijt Elien Doorduijn Vikas Dudeja Thorbald van Hall Eli Gilboa
author_sort	Greta Garrido
title	Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
title_short	Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
title_full	Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
title_fullStr	Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
title_full_unstemmed	Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
title_sort	tumor-targeted silencing of the peptide transporter tap induces potent antitumor immunity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9412b6e3bd1140079d62c6a2a9c464d0
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Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity

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