Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
The anti-tumour immune response greatly depends on the number of tumour neoantigens. Here the authors show in mouse models that a therapeutic strategy aimed at increasing the number of neoantigens via downregulating TAP, an antigen processing associated protein, enhances anti-tumour immunity and the...
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Autores principales: | Greta Garrido, Brett Schrand, Ailem Rabasa, Agata Levay, Francesca D’Eramo, Alexey Berezhnoy, Shrey Modi, Tal Gefen, Koen Marijt, Elien Doorduijn, Vikas Dudeja, Thorbald van Hall, Eli Gilboa |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/9412b6e3bd1140079d62c6a2a9c464d0 |
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