Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis

Al-Yacoub et al. investigate the consequences of FBXO32 mutation on dilated cardiomyopathy. ER stress, abnormal CHOP activation and CHOP-induced apoptosis with no UPR effector activation are found to underlie the FBXO32 mutation induced cardiomyopathy, suggesting an alternative pathway that can be c...

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Autores principales:	Nadya Al-Yacoub, Dilek Colak, Salma Awad Mahmoud, Maya Hammonds, Kunhi Muhammed, Olfat Al-Harazi, Abdullah M. Assiri, Jehad Al-Buraiki, Waleed Al-Habeeb, Coralie Poizat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9414570eeefe4652ac8f265170617ea4
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spelling	oai:doaj.org-article:9414570eeefe4652ac8f265170617ea42021-12-02T18:30:44ZMutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis10.1038/s42003-021-02391-92399-3642https://doaj.org/article/9414570eeefe4652ac8f265170617ea42021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02391-9https://doaj.org/toc/2399-3642Al-Yacoub et al. investigate the consequences of FBXO32 mutation on dilated cardiomyopathy. ER stress, abnormal CHOP activation and CHOP-induced apoptosis with no UPR effector activation are found to underlie the FBXO32 mutation induced cardiomyopathy, suggesting an alternative pathway that can be considered to develop new therapeutic targets for its treatment.Nadya Al-YacoubDilek ColakSalma Awad MahmoudMaya HammondsKunhi MuhammedOlfat Al-HaraziAbdullah M. AssiriJehad Al-BuraikiWaleed Al-HabeebCoralie PoizatNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nadya Al-Yacoub Dilek Colak Salma Awad Mahmoud Maya Hammonds Kunhi Muhammed Olfat Al-Harazi Abdullah M. Assiri Jehad Al-Buraiki Waleed Al-Habeeb Coralie Poizat Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis
description	Al-Yacoub et al. investigate the consequences of FBXO32 mutation on dilated cardiomyopathy. ER stress, abnormal CHOP activation and CHOP-induced apoptosis with no UPR effector activation are found to underlie the FBXO32 mutation induced cardiomyopathy, suggesting an alternative pathway that can be considered to develop new therapeutic targets for its treatment.
format	article
author	Nadya Al-Yacoub Dilek Colak Salma Awad Mahmoud Maya Hammonds Kunhi Muhammed Olfat Al-Harazi Abdullah M. Assiri Jehad Al-Buraiki Waleed Al-Habeeb Coralie Poizat
author_facet	Nadya Al-Yacoub Dilek Colak Salma Awad Mahmoud Maya Hammonds Kunhi Muhammed Olfat Al-Harazi Abdullah M. Assiri Jehad Al-Buraiki Waleed Al-Habeeb Coralie Poizat
author_sort	Nadya Al-Yacoub
title	Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis
title_short	Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis
title_full	Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis
title_fullStr	Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis
title_full_unstemmed	Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis
title_sort	mutation in fbxo32 causes dilated cardiomyopathy through up-regulation of er-stress mediated apoptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9414570eeefe4652ac8f265170617ea4
work_keys_str_mv	AT nadyaalyacoub mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT dilekcolak mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT salmaawadmahmoud mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT mayahammonds mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT kunhimuhammed mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT olfatalharazi mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT abdullahmassiri mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT jehadalburaiki mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT waleedalhabeeb mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis AT coraliepoizat mutationinfbxo32causesdilatedcardiomyopathythroughupregulationoferstressmediatedapoptosis
_version_	1718377993527623680

Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis

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