Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.

In tropical regions, protozoan parasites can cause severe diseases with malaria, leishmaniasis, sleeping sickness, and Chagas disease standing in the forefront. Many of the drugs currently being used to treat these diseases have been developed more than 50 years ago and can cause severe adverse effe...

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Autores principales:	Matthias Witschel, Matthias Rottmann, Marcel Kaiser, Reto Brun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/9415e1bfaea64edfa9d70ddfe9d43749
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spelling	oai:doaj.org-article:9415e1bfaea64edfa9d70ddfe9d437492021-11-18T09:15:44ZAgrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.1935-27271935-273510.1371/journal.pntd.0001805https://doaj.org/article/9415e1bfaea64edfa9d70ddfe9d437492012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145187/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735In tropical regions, protozoan parasites can cause severe diseases with malaria, leishmaniasis, sleeping sickness, and Chagas disease standing in the forefront. Many of the drugs currently being used to treat these diseases have been developed more than 50 years ago and can cause severe adverse effects. Above all, resistance to existing drugs is widespread and has become a serious problem threatening the success of control measures. In order to identify new antiprotozoal agents, more than 600 commercial agrochemicals have been tested on the pathogens causing the above mentioned diseases. For all of the pathogens, compounds were identified with similar or even higher activities than the currently used drugs in applied in vitro assays. Furthermore, in vivo activity was observed for the fungicide/oomyceticide azoxystrobin, and the insecticide hydramethylnon in the Plasmodium berghei mouse model, and for the oomyceticide zoxamide in the Trypanosoma brucei rhodesiense STIB900 mouse model, respectively.Matthias WitschelMatthias RottmannMarcel KaiserReto BrunPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 6, Iss 10, p e1805 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Matthias Witschel Matthias Rottmann Marcel Kaiser Reto Brun Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.
description	In tropical regions, protozoan parasites can cause severe diseases with malaria, leishmaniasis, sleeping sickness, and Chagas disease standing in the forefront. Many of the drugs currently being used to treat these diseases have been developed more than 50 years ago and can cause severe adverse effects. Above all, resistance to existing drugs is widespread and has become a serious problem threatening the success of control measures. In order to identify new antiprotozoal agents, more than 600 commercial agrochemicals have been tested on the pathogens causing the above mentioned diseases. For all of the pathogens, compounds were identified with similar or even higher activities than the currently used drugs in applied in vitro assays. Furthermore, in vivo activity was observed for the fungicide/oomyceticide azoxystrobin, and the insecticide hydramethylnon in the Plasmodium berghei mouse model, and for the oomyceticide zoxamide in the Trypanosoma brucei rhodesiense STIB900 mouse model, respectively.
format	article
author	Matthias Witschel Matthias Rottmann Marcel Kaiser Reto Brun
author_facet	Matthias Witschel Matthias Rottmann Marcel Kaiser Reto Brun
author_sort	Matthias Witschel
title	Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.
title_short	Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.
title_full	Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.
title_fullStr	Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.
title_full_unstemmed	Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.
title_sort	agrochemicals against malaria, sleeping sickness, leishmaniasis and chagas disease.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9415e1bfaea64edfa9d70ddfe9d43749
work_keys_str_mv	AT matthiaswitschel agrochemicalsagainstmalariasleepingsicknessleishmaniasisandchagasdisease AT matthiasrottmann agrochemicalsagainstmalariasleepingsicknessleishmaniasisandchagasdisease AT marcelkaiser agrochemicalsagainstmalariasleepingsicknessleishmaniasisandchagasdisease AT retobrun agrochemicalsagainstmalariasleepingsicknessleishmaniasisandchagasdisease
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Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.

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