DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

Although Huntington’s disease (HD) is a well-studied genetic disorder, less is known about the epigenetic changes underlying it. Here, the authors characterize DNA methylation levels in tissues from patients, a mouse huntingtin (Htt) gene knock-in model, and a transgenic HTT sheep model, and provide...

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Autores principales:	Ake T. Lu, Pritika Narayan, Matthew J. Grant, Peter Langfelder, Nan Wang, Seung Kwak, Hilary Wilkinson, Richard Z. Chen, Jian Chen, C. Simon Bawden, Skye R. Rudiger, Marc Ciosi, Afroditi Chatzi, Alastair Maxwell, Timothy A. Hore, Jeff Aaronson, Jim Rosinski, Alicia Preiss, Thomas F. Vogt, Giovanni Coppola, Darren Monckton, Russell G. Snell, X. William Yang, Steve Horvath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9415f3c0bb6441ffad6d13aeb09b8ee8
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spelling	oai:doaj.org-article:9415f3c0bb6441ffad6d13aeb09b8ee82021-12-02T17:42:11ZDNA methylation study of Huntington’s disease and motor progression in patients and in animal models10.1038/s41467-020-18255-52041-1723https://doaj.org/article/9415f3c0bb6441ffad6d13aeb09b8ee82020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18255-5https://doaj.org/toc/2041-1723Although Huntington’s disease (HD) is a well-studied genetic disorder, less is known about the epigenetic changes underlying it. Here, the authors characterize DNA methylation levels in tissues from patients, a mouse huntingtin (Htt) gene knock-in model, and a transgenic HTT sheep model, and provide evidence that HD is accompanied by DNA methylation changes in these three species.Ake T. LuPritika NarayanMatthew J. GrantPeter LangfelderNan WangSeung KwakHilary WilkinsonRichard Z. ChenJian ChenC. Simon BawdenSkye R. RudigerMarc CiosiAfroditi ChatziAlastair MaxwellTimothy A. HoreJeff AaronsonJim RosinskiAlicia PreissThomas F. VogtGiovanni CoppolaDarren MoncktonRussell G. SnellX. William YangSteve HorvathNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ake T. Lu Pritika Narayan Matthew J. Grant Peter Langfelder Nan Wang Seung Kwak Hilary Wilkinson Richard Z. Chen Jian Chen C. Simon Bawden Skye R. Rudiger Marc Ciosi Afroditi Chatzi Alastair Maxwell Timothy A. Hore Jeff Aaronson Jim Rosinski Alicia Preiss Thomas F. Vogt Giovanni Coppola Darren Monckton Russell G. Snell X. William Yang Steve Horvath DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
description	Although Huntington’s disease (HD) is a well-studied genetic disorder, less is known about the epigenetic changes underlying it. Here, the authors characterize DNA methylation levels in tissues from patients, a mouse huntingtin (Htt) gene knock-in model, and a transgenic HTT sheep model, and provide evidence that HD is accompanied by DNA methylation changes in these three species.
format	article
author	Ake T. Lu Pritika Narayan Matthew J. Grant Peter Langfelder Nan Wang Seung Kwak Hilary Wilkinson Richard Z. Chen Jian Chen C. Simon Bawden Skye R. Rudiger Marc Ciosi Afroditi Chatzi Alastair Maxwell Timothy A. Hore Jeff Aaronson Jim Rosinski Alicia Preiss Thomas F. Vogt Giovanni Coppola Darren Monckton Russell G. Snell X. William Yang Steve Horvath
author_facet	Ake T. Lu Pritika Narayan Matthew J. Grant Peter Langfelder Nan Wang Seung Kwak Hilary Wilkinson Richard Z. Chen Jian Chen C. Simon Bawden Skye R. Rudiger Marc Ciosi Afroditi Chatzi Alastair Maxwell Timothy A. Hore Jeff Aaronson Jim Rosinski Alicia Preiss Thomas F. Vogt Giovanni Coppola Darren Monckton Russell G. Snell X. William Yang Steve Horvath
author_sort	Ake T. Lu
title	DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
title_short	DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
title_full	DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
title_fullStr	DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
title_full_unstemmed	DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
title_sort	dna methylation study of huntington’s disease and motor progression in patients and in animal models
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9415f3c0bb6441ffad6d13aeb09b8ee8
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DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

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