A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”

ABSTRACT Microbes drive critical ecosystem functions and affect global nutrient cycling along with human health and disease. They do so under strong constraints exerted by viruses, which shape microbial communities’ structure and shift host cell metabolism during infection. While the majority of vir...

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Autor principal:	Simon Roux
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	ecogenomics metagenomics phage virus Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/941c15b7ad6b4bf290cce34c9833f166
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spelling	oai:doaj.org-article:941c15b7ad6b4bf290cce34c9833f1662021-12-02T19:46:18ZA Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”10.1128/mSystems.00111-192379-5077https://doaj.org/article/941c15b7ad6b4bf290cce34c9833f1662019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00111-19https://doaj.org/toc/2379-5077ABSTRACT Microbes drive critical ecosystem functions and affect global nutrient cycling along with human health and disease. They do so under strong constraints exerted by viruses, which shape microbial communities’ structure and shift host cell metabolism during infection. While the majority of viruses and their associated impacts remain poorly characterized, a number of mechanisms by which viruses alter microbial cells and ecosystems have already been revealed. Here I outline how a comprehensive host-resolved mapping of viral sequence space will enable a thorough characterization of virus-encoded mechanisms for microbial manipulation. With soon-to-be millions of virus genomes obtained from metagenomes, one of the major challenges resides in the development of methods for high-throughput and high-resolution virus-host pairing, before multi-omics approaches can be leveraged to fully decipher virus-host dynamics in nature. Beyond novel fundamental biological knowledge, these studies will likely provide new molecular tools enabling a precise engineering of microbial cells and communities.Simon RouxAmerican Society for MicrobiologyarticleecogenomicsmetagenomicsphagevirusMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ecogenomics metagenomics phage virus Microbiology QR1-502
spellingShingle	ecogenomics metagenomics phage virus Microbiology QR1-502 Simon Roux A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”
description	ABSTRACT Microbes drive critical ecosystem functions and affect global nutrient cycling along with human health and disease. They do so under strong constraints exerted by viruses, which shape microbial communities’ structure and shift host cell metabolism during infection. While the majority of viruses and their associated impacts remain poorly characterized, a number of mechanisms by which viruses alter microbial cells and ecosystems have already been revealed. Here I outline how a comprehensive host-resolved mapping of viral sequence space will enable a thorough characterization of virus-encoded mechanisms for microbial manipulation. With soon-to-be millions of virus genomes obtained from metagenomes, one of the major challenges resides in the development of methods for high-throughput and high-resolution virus-host pairing, before multi-omics approaches can be leveraged to fully decipher virus-host dynamics in nature. Beyond novel fundamental biological knowledge, these studies will likely provide new molecular tools enabling a precise engineering of microbial cells and communities.
format	article
author	Simon Roux
author_facet	Simon Roux
author_sort	Simon Roux
title	A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”
title_short	A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”
title_full	A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”
title_fullStr	A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”
title_full_unstemmed	A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”
title_sort	viral ecogenomics framework to uncover the secrets of nature’s “microbe whisperers”
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/941c15b7ad6b4bf290cce34c9833f166
work_keys_str_mv	AT simonroux aviralecogenomicsframeworktouncoverthesecretsofnaturesmicrobewhisperers AT simonroux viralecogenomicsframeworktouncoverthesecretsofnaturesmicrobewhisperers
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A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”

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