Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound

Abstract The central nervous system (CNS) controls skeletal muscles by the recruitment of motor units (MUs). Understanding MU function is critical in the diagnosis of neuromuscular diseases, exercise physiology and sports, and rehabilitation medicine. Recording and analyzing the MUs’ electrical depo...

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Autores principales:	Robin Rohlén, Erik Stålberg, Christer Grönlund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/941c7b4a9ee640bb8f1d6583446d4278
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spelling	oai:doaj.org-article:941c7b4a9ee640bb8f1d6583446d42782021-12-02T12:53:17ZIdentification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound10.1038/s41598-020-79863-12045-2322https://doaj.org/article/941c7b4a9ee640bb8f1d6583446d42782020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79863-1https://doaj.org/toc/2045-2322Abstract The central nervous system (CNS) controls skeletal muscles by the recruitment of motor units (MUs). Understanding MU function is critical in the diagnosis of neuromuscular diseases, exercise physiology and sports, and rehabilitation medicine. Recording and analyzing the MUs’ electrical depolarization is the basis for state-of-the-art methods. Ultrafast ultrasound is a method that has the potential to study MUs because of the electrical depolarizations and consequent mechanical twitches. In this study, we evaluate if single MUs and their mechanical twitches can be identified using ultrafast ultrasound imaging of voluntary contractions. We compared decomposed spatio-temporal components of ultrasound image sequences against the gold standard needle electromyography. We found that 31% of the MUs could be successfully located and their firing pattern extracted. This method allows new non-invasive opportunities to study mechanical properties of MUs and the CNS control in neuromuscular physiology.Robin RohlénErik StålbergChrister GrönlundNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robin Rohlén Erik Stålberg Christer Grönlund Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound
description	Abstract The central nervous system (CNS) controls skeletal muscles by the recruitment of motor units (MUs). Understanding MU function is critical in the diagnosis of neuromuscular diseases, exercise physiology and sports, and rehabilitation medicine. Recording and analyzing the MUs’ electrical depolarization is the basis for state-of-the-art methods. Ultrafast ultrasound is a method that has the potential to study MUs because of the electrical depolarizations and consequent mechanical twitches. In this study, we evaluate if single MUs and their mechanical twitches can be identified using ultrafast ultrasound imaging of voluntary contractions. We compared decomposed spatio-temporal components of ultrasound image sequences against the gold standard needle electromyography. We found that 31% of the MUs could be successfully located and their firing pattern extracted. This method allows new non-invasive opportunities to study mechanical properties of MUs and the CNS control in neuromuscular physiology.
format	article
author	Robin Rohlén Erik Stålberg Christer Grönlund
author_facet	Robin Rohlén Erik Stålberg Christer Grönlund
author_sort	Robin Rohlén
title	Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound
title_short	Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound
title_full	Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound
title_fullStr	Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound
title_full_unstemmed	Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound
title_sort	identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/941c7b4a9ee640bb8f1d6583446d4278
work_keys_str_mv	AT robinrohlen identificationofsinglemotorunitsinskeletalmuscleunderlowforceisometricvoluntarycontractionsusingultrafastultrasound AT erikstalberg identificationofsinglemotorunitsinskeletalmuscleunderlowforceisometricvoluntarycontractionsusingultrafastultrasound AT christergronlund identificationofsinglemotorunitsinskeletalmuscleunderlowforceisometricvoluntarycontractionsusingultrafastultrasound
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Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound

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