In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation

It is unclear how the T-tubule structure of skeletal muscle, which regulates coordinated muscle contraction, forms. Here, the authors develop a four-dimensional quantitative model for T-tubule formation in zebrafish, based on live imaging, proposing a dynamic endocytic capture model.

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Detalles Bibliográficos
Autores principales: Thomas E. Hall, Nick Martel, Nicholas Ariotti, Zherui Xiong, Harriet P. Lo, Charles Ferguson, James Rae, Ye-Wheen Lim, Robert G. Parton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/941cb3d60f0f45e1a240d47b1985557b
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Descripción
Sumario:It is unclear how the T-tubule structure of skeletal muscle, which regulates coordinated muscle contraction, forms. Here, the authors develop a four-dimensional quantitative model for T-tubule formation in zebrafish, based on live imaging, proposing a dynamic endocytic capture model.