Frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer

Aims. To study at greater than before material the prevalence of type 2 diabetes (T2DM) in relatives of suffering from T2DM patients with cancer and compare the features of antidiabetic therapy in cancer patients with a familial and non-familial form of diabetes.Materials and Methods. Information ab...

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Autores principales:	Lev Mikhaylovich Berstein, Svetlana Yuryevna Teslenko, Dmitry Alekseevich Vasilyev, Irina Mikhaylovna Kovalenko
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	type 2 diabetes family history of diabetes cancer antidiabetic therapy metformin Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/941d6c6537a64f239bfb3adb65a55727
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spelling	oai:doaj.org-article:941d6c6537a64f239bfb3adb65a557272021-11-14T09:00:19ZFrequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer2072-03512072-037810.14341/DM2015377-84https://doaj.org/article/941d6c6537a64f239bfb3adb65a557272015-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7105https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. To study at greater than before material the prevalence of type 2 diabetes (T2DM) in relatives of suffering from T2DM patients with cancer and compare the features of antidiabetic therapy in cancer patients with a familial and non-familial form of diabetes.Materials and Methods. Information about diabetes history in family was collected during two subsequent periods (May 2009-February 2011 and March 2011-July 2014 years) in cancer patients (totally,1955 people; 1351 of them with T2DM and 604 without diabetes), as well as in patients with T2DM without cancer (n=379). All patients answered questions about diabetes in their mothers, fathers, siblings, and other relatives. In cancer patients with T2DM, data on the type of antidiabetic therapy for at least 6 months prior to enrolling into the hospital were collected.Results. A lower frequency of family diabetes in diabetic patients with cancer (28,5±1,2% vs 38,0±2,5%, p<0.01 in T2DM without cancer) was revealed. By 2011–2014 the prevalence of family diabetes was grown significantly and virtually in a similar degree in both groups (+17,9% in ‘T2DM with cancer’ and +19,3% in ‘T2DM without cancer’). T2DM patients with cancer and family history of diabetes used metformin prior hospitalization more often than same patients without familial T2DM.Conclusion. Reaffirming the earlier data on more infrequent occurrence of family diabetes in T2DM patients with cancer compared with T2DM patients without cancer, we were able to demonstrate roughly the same increase in the detection of familial diabetes in these groups of patients in a rather short period of time. The use of metformin – one of the potential factors contributing to the probable and unexpected decrease of cancer risk in T2DM patients with familial type of diabetes. Other possible causes of this phenomenon deserve further study in view of the growing epidemic of diabetes and obesity.Lev Mikhaylovich BersteinSvetlana Yuryevna TeslenkoDmitry Alekseevich VasilyevIrina Mikhaylovna KovalenkoEndocrinology Research Centrearticletype 2 diabetesfamily history of diabetescancerantidiabetic therapymetforminNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 3, Pp 77-84 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes family history of diabetes cancer antidiabetic therapy metformin Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes family history of diabetes cancer antidiabetic therapy metformin Nutritional diseases. Deficiency diseases RC620-627 Lev Mikhaylovich Berstein Svetlana Yuryevna Teslenko Dmitry Alekseevich Vasilyev Irina Mikhaylovna Kovalenko Frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer
description	Aims. To study at greater than before material the prevalence of type 2 diabetes (T2DM) in relatives of suffering from T2DM patients with cancer and compare the features of antidiabetic therapy in cancer patients with a familial and non-familial form of diabetes.Materials and Methods. Information about diabetes history in family was collected during two subsequent periods (May 2009-February 2011 and March 2011-July 2014 years) in cancer patients (totally,1955 people; 1351 of them with T2DM and 604 without diabetes), as well as in patients with T2DM without cancer (n=379). All patients answered questions about diabetes in their mothers, fathers, siblings, and other relatives. In cancer patients with T2DM, data on the type of antidiabetic therapy for at least 6 months prior to enrolling into the hospital were collected.Results. A lower frequency of family diabetes in diabetic patients with cancer (28,5±1,2% vs 38,0±2,5%, p<0.01 in T2DM without cancer) was revealed. By 2011–2014 the prevalence of family diabetes was grown significantly and virtually in a similar degree in both groups (+17,9% in ‘T2DM with cancer’ and +19,3% in ‘T2DM without cancer’). T2DM patients with cancer and family history of diabetes used metformin prior hospitalization more often than same patients without familial T2DM.Conclusion. Reaffirming the earlier data on more infrequent occurrence of family diabetes in T2DM patients with cancer compared with T2DM patients without cancer, we were able to demonstrate roughly the same increase in the detection of familial diabetes in these groups of patients in a rather short period of time. The use of metformin – one of the potential factors contributing to the probable and unexpected decrease of cancer risk in T2DM patients with familial type of diabetes. Other possible causes of this phenomenon deserve further study in view of the growing epidemic of diabetes and obesity.
format	article
author	Lev Mikhaylovich Berstein Svetlana Yuryevna Teslenko Dmitry Alekseevich Vasilyev Irina Mikhaylovna Kovalenko
author_facet	Lev Mikhaylovich Berstein Svetlana Yuryevna Teslenko Dmitry Alekseevich Vasilyev Irina Mikhaylovna Kovalenko
author_sort	Lev Mikhaylovich Berstein
title	Frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer
title_short	Frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer
title_full	Frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer
title_fullStr	Frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer
title_full_unstemmed	Frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer
title_sort	frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/941d6c6537a64f239bfb3adb65a55727
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Frequency of type 2 diabetes in family and it’s changes in diabetic patients affected or not affected with cancer

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