Habenula GPR139 is associated with fear learning in the zebrafish

Abstract G-protein coupled receptor 139 (GPR139) is an evolutionarily conserved orphan receptor, predominantly expressing in the habenula of vertebrate species. The habenula has recently been implicated in aversive response and its associated learning. Here, we tested the hypothesis that GPR139 sign...

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Autores principales:	Nisa Roy, Satoshi Ogawa, Roshan Maniam, Ishwar Parhar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/941f840711fb4d1a8f142f93f267a263
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spelling	oai:doaj.org-article:941f840711fb4d1a8f142f93f267a2632021-12-02T15:54:10ZHabenula GPR139 is associated with fear learning in the zebrafish10.1038/s41598-021-85002-12045-2322https://doaj.org/article/941f840711fb4d1a8f142f93f267a2632021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85002-1https://doaj.org/toc/2045-2322Abstract G-protein coupled receptor 139 (GPR139) is an evolutionarily conserved orphan receptor, predominantly expressing in the habenula of vertebrate species. The habenula has recently been implicated in aversive response and its associated learning. Here, we tested the hypothesis that GPR139 signalling in the habenula may play a role in fear learning in the zebrafish. We examined the effect of intraperitoneal injections of a human GPR139-selective agonist (JNJ-63533054) on alarm substance-induced fear learning using conditioned place avoidance paradigm, where an aversive stimulus is paired with one compartment, while its absence is associated with the other compartment of the apparatus. The results indicate that fish treated with 1 µg/g body weight of GPR139 agonist displayed no difference in locomotor activity and alarm substance-induced fear response. However, avoidance to fear-conditioned compartment was diminished, which suggests that the agonist blocks the consolidation of contextual fear memory. On the other hand, fish treated with 0.1 µg/g body weight of GPR139 agonist spent a significantly longer time in the unconditioned neutral compartment as compared to the conditioned (punished and unpunished) compartments. These results suggest that activation of GPR139 signalling in the habenula may be involved in fear learning and the decision-making process in the zebrafish.Nisa RoySatoshi OgawaRoshan ManiamIshwar ParharNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nisa Roy Satoshi Ogawa Roshan Maniam Ishwar Parhar Habenula GPR139 is associated with fear learning in the zebrafish
description	Abstract G-protein coupled receptor 139 (GPR139) is an evolutionarily conserved orphan receptor, predominantly expressing in the habenula of vertebrate species. The habenula has recently been implicated in aversive response and its associated learning. Here, we tested the hypothesis that GPR139 signalling in the habenula may play a role in fear learning in the zebrafish. We examined the effect of intraperitoneal injections of a human GPR139-selective agonist (JNJ-63533054) on alarm substance-induced fear learning using conditioned place avoidance paradigm, where an aversive stimulus is paired with one compartment, while its absence is associated with the other compartment of the apparatus. The results indicate that fish treated with 1 µg/g body weight of GPR139 agonist displayed no difference in locomotor activity and alarm substance-induced fear response. However, avoidance to fear-conditioned compartment was diminished, which suggests that the agonist blocks the consolidation of contextual fear memory. On the other hand, fish treated with 0.1 µg/g body weight of GPR139 agonist spent a significantly longer time in the unconditioned neutral compartment as compared to the conditioned (punished and unpunished) compartments. These results suggest that activation of GPR139 signalling in the habenula may be involved in fear learning and the decision-making process in the zebrafish.
format	article
author	Nisa Roy Satoshi Ogawa Roshan Maniam Ishwar Parhar
author_facet	Nisa Roy Satoshi Ogawa Roshan Maniam Ishwar Parhar
author_sort	Nisa Roy
title	Habenula GPR139 is associated with fear learning in the zebrafish
title_short	Habenula GPR139 is associated with fear learning in the zebrafish
title_full	Habenula GPR139 is associated with fear learning in the zebrafish
title_fullStr	Habenula GPR139 is associated with fear learning in the zebrafish
title_full_unstemmed	Habenula GPR139 is associated with fear learning in the zebrafish
title_sort	habenula gpr139 is associated with fear learning in the zebrafish
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/941f840711fb4d1a8f142f93f267a263
work_keys_str_mv	AT nisaroy habenulagpr139isassociatedwithfearlearninginthezebrafish AT satoshiogawa habenulagpr139isassociatedwithfearlearninginthezebrafish AT roshanmaniam habenulagpr139isassociatedwithfearlearninginthezebrafish AT ishwarparhar habenulagpr139isassociatedwithfearlearninginthezebrafish
_version_	1718385462840655872

Habenula GPR139 is associated with fear learning in the zebrafish

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