Obesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study

Although both obesity and menopause are associated with increased risk of diabetes mellitus (DM), the association between obesity and DM according to menopausal status remains uncertain. Therefore, we conducted a study to examine the relationship between obesity and incidence of diabetes mellitus (D...

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Autores principales:	Han Rim Lee, Jungeun Shin, Kyungdo Han, Jiwon Chang, Su-Min Jeong, Seung Joo Chon, Soo Jung Choi, Dong Wook Shin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes mellitus obesity menopause Medicine R
Acceso en línea:	https://doaj.org/article/9420652e775047489fbf05b137377d31
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spelling	oai:doaj.org-article:9420652e775047489fbf05b137377d312021-11-11T17:47:45ZObesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study10.3390/jcm102151892077-0383https://doaj.org/article/9420652e775047489fbf05b137377d312021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5189https://doaj.org/toc/2077-0383Although both obesity and menopause are associated with increased risk of diabetes mellitus (DM), the association between obesity and DM according to menopausal status remains uncertain. Therefore, we conducted a study to examine the relationship between obesity and incidence of diabetes mellitus (DM) in premenopausal and postmenopausal women. Total of 926,196 premenopausal and 1,193,881 postmenopausal women who underwent health examinations from 2009 to 2014 were identified using the database of the Korean National Health Insurance Service. We compared the incidence and risk of DM according to body mass index (BMI) and waist circumference (WC) in the two groups of women. Cox proportional hazards analyses were performed to evaluate the association between the presence of obesity and risk of DM according to menopausal state. During the 7.8-year follow-up period, 37,736 (4.1%) premenopausal women and 121,102 (10.1%) postmenopausal women were diagnosed with DM. Compared to the reference group (BMI 18.5–23), a stronger association between obesity and risk of DM was observed in both pre- and postmenopausal women: multivariable-adjusted hazard ratios and 95% confidence intervals for BMI subgroups <18.5, 23–25, 25–30, and >30 were 0.62 (0.54, 0.70), 1.91 (1.85, 1.97), 3.38 (3.28, 3.47), and 6.25 (6.02, 6.48), respectively (<i>p</i> trend < 0.001) in premenopausal women and 0.87 (0.82, 0.92), 1.44 (1.41, 1.46), 2.00 (1.97, 2.03), and 2.96 (2.89, 3.02) in postmenopausal women (<i>p</i> trend < 0.001, <i>p</i>-interaction < 0.001). A similar trend was observed for WC. Subgroup analyses of women aged 45 to 55 also showed a stronger association with DM in premenopausal than in postmenopausal women. In conclusion, the association between obesity and DM was stronger in premenopausal women than in postmenopausal women. As estrogens are synthesized in adipose tissue by aromatization of androgens after menopause, increased estrogen levels in obese postmenopausal might have a protective effect against DM.Han Rim LeeJungeun ShinKyungdo HanJiwon ChangSu-Min JeongSeung Joo ChonSoo Jung ChoiDong Wook ShinMDPI AGarticlediabetes mellitusobesitymenopauseMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5189, p 5189 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus obesity menopause Medicine R
spellingShingle	diabetes mellitus obesity menopause Medicine R Han Rim Lee Jungeun Shin Kyungdo Han Jiwon Chang Su-Min Jeong Seung Joo Chon Soo Jung Choi Dong Wook Shin Obesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study
description	Although both obesity and menopause are associated with increased risk of diabetes mellitus (DM), the association between obesity and DM according to menopausal status remains uncertain. Therefore, we conducted a study to examine the relationship between obesity and incidence of diabetes mellitus (DM) in premenopausal and postmenopausal women. Total of 926,196 premenopausal and 1,193,881 postmenopausal women who underwent health examinations from 2009 to 2014 were identified using the database of the Korean National Health Insurance Service. We compared the incidence and risk of DM according to body mass index (BMI) and waist circumference (WC) in the two groups of women. Cox proportional hazards analyses were performed to evaluate the association between the presence of obesity and risk of DM according to menopausal state. During the 7.8-year follow-up period, 37,736 (4.1%) premenopausal women and 121,102 (10.1%) postmenopausal women were diagnosed with DM. Compared to the reference group (BMI 18.5–23), a stronger association between obesity and risk of DM was observed in both pre- and postmenopausal women: multivariable-adjusted hazard ratios and 95% confidence intervals for BMI subgroups <18.5, 23–25, 25–30, and >30 were 0.62 (0.54, 0.70), 1.91 (1.85, 1.97), 3.38 (3.28, 3.47), and 6.25 (6.02, 6.48), respectively (<i>p</i> trend < 0.001) in premenopausal women and 0.87 (0.82, 0.92), 1.44 (1.41, 1.46), 2.00 (1.97, 2.03), and 2.96 (2.89, 3.02) in postmenopausal women (<i>p</i> trend < 0.001, <i>p</i>-interaction < 0.001). A similar trend was observed for WC. Subgroup analyses of women aged 45 to 55 also showed a stronger association with DM in premenopausal than in postmenopausal women. In conclusion, the association between obesity and DM was stronger in premenopausal women than in postmenopausal women. As estrogens are synthesized in adipose tissue by aromatization of androgens after menopause, increased estrogen levels in obese postmenopausal might have a protective effect against DM.
format	article
author	Han Rim Lee Jungeun Shin Kyungdo Han Jiwon Chang Su-Min Jeong Seung Joo Chon Soo Jung Choi Dong Wook Shin
author_facet	Han Rim Lee Jungeun Shin Kyungdo Han Jiwon Chang Su-Min Jeong Seung Joo Chon Soo Jung Choi Dong Wook Shin
author_sort	Han Rim Lee
title	Obesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study
title_short	Obesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study
title_full	Obesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study
title_fullStr	Obesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study
title_full_unstemmed	Obesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study
title_sort	obesity and risk of diabetes mellitus by menopausal status: a nationwide cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9420652e775047489fbf05b137377d31
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Obesity and Risk of Diabetes Mellitus by Menopausal Status: A Nationwide Cohort Study

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