Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database

Sophie Liabeuf,1–3 Valérie Gras,1 Julien Moragny,1 Marie-Laure Laroche,4 Michel Andrejak1,3On behalf of the French National Network of Pharmacovigilance Centers1Regional Pharmacovigilance Center, Division of Clinical Pharmacology, Amiens University Medical Center and Jules Verne...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liabeuf S, Gras V, Moragny J, Laroche ML, Andrejak M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	ferrous sulfate drug ulceration oral ulceration elderly Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/9421b8b089774486a97290e652018d49
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9421b8b089774486a97290e652018d49
record_format	dspace
spelling	oai:doaj.org-article:9421b8b089774486a97290e652018d492021-12-02T09:47:11ZUlceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database1178-1998https://doaj.org/article/9421b8b089774486a97290e652018d492014-04-01T00:00:00Zhttps://www.dovepress.com/ulceration-of-the-oral-mucosa-following-direct-contact-with-ferrous-su-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Sophie Liabeuf,1–3 Valérie Gras,1 Julien Moragny,1 Marie-Laure Laroche,4 Michel Andrejak1,3On behalf of the French National Network of Pharmacovigilance Centers1Regional Pharmacovigilance Center, Division of Clinical Pharmacology, Amiens University Medical Center and Jules Verne University of Picardy, Amiens, France; 2Clinical Research Centre, Clinical Pharmacology Division, Amiens University Medical Center and the Jules Verne University of Picardy, Amiens, France; 3INSERM U1088, Amiens, France; 4Regional Pharmacovigilance Center, Department of Pharmacology, Toxicology and Pharmacovigilance, Limoges University Medical Center, Limoges, FranceObjective: To report a series of cases of ulceration of the oral mucosa linked to direct contact with ferrous sulfate in elderly patients.Case summary: The first case report concerns the occurrence of widespread oral ulceration in an 87-year-old woman with Alzheimer’s disease. The ulceration extended from the side of the tongue to the floor of the mouth. No clear explanation was found and various local treatments were ineffective. Once it was realized that the ferrous sulfate tablets (given as an iron supplement) were crushed prior to administration (due to the patient’s deglutition disorder), withdrawal of this treatment led to rapid resolution of the ulceration. Nine other cases of oral ulcerations associated with ferrous sulfate were identified in the French National Pharmacovigilance Database. All but one of the patients were over 80 years of age and the youngest patient (a 54-year-old) had dysphagia associated with facial paralysis.Discussion: Only two other reports of oral ulceration due to ferrous sulfate have been published to date. Mucosal toxicity of ferrous sulfate (which is probably related to oxidative stress) has previously been reported for the hypopharynx, the esophageal lumen, and (after inhalation of a tablet) the tracheobronchial tree.Conclusion: The mucosal toxicity of ferrous sulfate must be taken into account when deglutition disorders are present (as in elderly patients) and appropriate pharmaceutical formulations (such as syrups) should be administered to at-risk patients. The use of iron salts other than ferrous sulfate could be considered.Keywords: ferrous sulfate, drug ulceration, oral ulceration, elderlyLiabeuf SGras VMoragny JLaroche MLAndrejak MDove Medical Pressarticleferrous sulfatedrug ulcerationoral ulcerationelderlyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 737-740 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferrous sulfate drug ulceration oral ulceration elderly Geriatrics RC952-954.6
spellingShingle	ferrous sulfate drug ulceration oral ulceration elderly Geriatrics RC952-954.6 Liabeuf S Gras V Moragny J Laroche ML Andrejak M Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database
description	Sophie Liabeuf,1–3 Valérie Gras,1 Julien Moragny,1 Marie-Laure Laroche,4 Michel Andrejak1,3On behalf of the French National Network of Pharmacovigilance Centers1Regional Pharmacovigilance Center, Division of Clinical Pharmacology, Amiens University Medical Center and Jules Verne University of Picardy, Amiens, France; 2Clinical Research Centre, Clinical Pharmacology Division, Amiens University Medical Center and the Jules Verne University of Picardy, Amiens, France; 3INSERM U1088, Amiens, France; 4Regional Pharmacovigilance Center, Department of Pharmacology, Toxicology and Pharmacovigilance, Limoges University Medical Center, Limoges, FranceObjective: To report a series of cases of ulceration of the oral mucosa linked to direct contact with ferrous sulfate in elderly patients.Case summary: The first case report concerns the occurrence of widespread oral ulceration in an 87-year-old woman with Alzheimer’s disease. The ulceration extended from the side of the tongue to the floor of the mouth. No clear explanation was found and various local treatments were ineffective. Once it was realized that the ferrous sulfate tablets (given as an iron supplement) were crushed prior to administration (due to the patient’s deglutition disorder), withdrawal of this treatment led to rapid resolution of the ulceration. Nine other cases of oral ulcerations associated with ferrous sulfate were identified in the French National Pharmacovigilance Database. All but one of the patients were over 80 years of age and the youngest patient (a 54-year-old) had dysphagia associated with facial paralysis.Discussion: Only two other reports of oral ulceration due to ferrous sulfate have been published to date. Mucosal toxicity of ferrous sulfate (which is probably related to oxidative stress) has previously been reported for the hypopharynx, the esophageal lumen, and (after inhalation of a tablet) the tracheobronchial tree.Conclusion: The mucosal toxicity of ferrous sulfate must be taken into account when deglutition disorders are present (as in elderly patients) and appropriate pharmaceutical formulations (such as syrups) should be administered to at-risk patients. The use of iron salts other than ferrous sulfate could be considered.Keywords: ferrous sulfate, drug ulceration, oral ulceration, elderly
format	article
author	Liabeuf S Gras V Moragny J Laroche ML Andrejak M
author_facet	Liabeuf S Gras V Moragny J Laroche ML Andrejak M
author_sort	Liabeuf S
title	Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database
title_short	Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database
title_full	Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database
title_fullStr	Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database
title_full_unstemmed	Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database
title_sort	ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the french national pharmacovigilance database
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/9421b8b089774486a97290e652018d49
work_keys_str_mv	AT liabeufs ulcerationoftheoralmucosafollowingdirectcontactwithferroussulfateinelderlypatientsacasereportandareviewofthefrenchnationalpharmacovigilancedatabase AT grasv ulcerationoftheoralmucosafollowingdirectcontactwithferroussulfateinelderlypatientsacasereportandareviewofthefrenchnationalpharmacovigilancedatabase AT moragnyj ulcerationoftheoralmucosafollowingdirectcontactwithferroussulfateinelderlypatientsacasereportandareviewofthefrenchnationalpharmacovigilancedatabase AT larocheml ulcerationoftheoralmucosafollowingdirectcontactwithferroussulfateinelderlypatientsacasereportandareviewofthefrenchnationalpharmacovigilancedatabase AT andrejakm ulcerationoftheoralmucosafollowingdirectcontactwithferroussulfateinelderlypatientsacasereportandareviewofthefrenchnationalpharmacovigilancedatabase
_version_	1718398018691006464

Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database

Ejemplares similares