PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in vivo.

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Autores principales:	Ling Guo, Chunhong Cui, Jiaxin Wang, Jifan Yuan, Qingyang Yang, Ping Zhang, Wen Su, Ruolu Bao, Jingchao Ran, Chuanyue Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9424d0611639496d99200fb2dc001180
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spelling	oai:doaj.org-article:9424d0611639496d99200fb2dc0011802021-12-02T18:51:30ZPINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth10.1038/s41467-020-18753-62041-1723https://doaj.org/article/9424d0611639496d99200fb2dc0011802020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18753-6https://doaj.org/toc/2041-1723Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in vivo.Ling GuoChunhong CuiJiaxin WangJifan YuanQingyang YangPing ZhangWen SuRuolu BaoJingchao RanChuanyue WuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ling Guo Chunhong Cui Jiaxin Wang Jifan Yuan Qingyang Yang Ping Zhang Wen Su Ruolu Bao Jingchao Ran Chuanyue Wu PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
description	Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in vivo.
format	article
author	Ling Guo Chunhong Cui Jiaxin Wang Jifan Yuan Qingyang Yang Ping Zhang Wen Su Ruolu Bao Jingchao Ran Chuanyue Wu
author_facet	Ling Guo Chunhong Cui Jiaxin Wang Jifan Yuan Qingyang Yang Ping Zhang Wen Su Ruolu Bao Jingchao Ran Chuanyue Wu
author_sort	Ling Guo
title	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_short	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_full	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_fullStr	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_full_unstemmed	PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
title_sort	pinch-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9424d0611639496d99200fb2dc001180
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PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

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